1887178-64-4
1887178-64-4 structure
- Name: MI-1481
- Chemical Name: MI-1481
- CAS Number: 1887178-64-4
- Molecular Formula: C29H30F3N7O2S
- Molecular Weight: 597.661
- Catalog: Research Areas Cancer
- Create Date: 2020-01-12 10:22:50
- Modify Date: 2024-02-07 23:13:55
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MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6 nM, 10-fold increase in inhibitory activity over MI-463 and MI-503; markedly reduces cell growth of murine bone marrow cells transformed with MLL-AF9 with GI50 of 34 nM, demonstrates potent on target activity in MLL leukemia cells with GI50 values of 36 nM in MV4;11 (harboring MLL-AF4 fusion protein) and 61 nM in MOLM13 (harboring MLL-AF9); downregulates the MLL fusion protein target genes, HOXA9 and MEIS1, at 100 nMin MV4;11 human MLL leukemia cells; strongly inhibits leukemia progression in vivo.
| Name | MI-1481 |
|---|
| Description | MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6 nM, 10-fold increase in inhibitory activity over MI-463 and MI-503; markedly reduces cell growth of murine bone marrow cells transformed with MLL-AF9 with GI50 of 34 nM, demonstrates potent on target activity in MLL leukemia cells with GI50 values of 36 nM in MV4;11 (harboring MLL-AF4 fusion protein) and 61 nM in MOLM13 (harboring MLL-AF9); downregulates the MLL fusion protein target genes, HOXA9 and MEIS1, at 100 nMin MV4;11 human MLL leukemia cells; strongly inhibits leukemia progression in vivo. |
|---|---|
| References | References 1. Borkin D, et al. J Med Chem. 2018 May 23. doi: 10.1021/acs.jmedchem.8b00071. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C29H30F3N7O2S |
|---|---|
| Molecular Weight | 597.661 |