NLRP3-IN-2

Modify Date: 2025-08-21 01:54:36

NLRP3-IN-2 Structure
NLRP3-IN-2 structure
 Common Name NLRP3-IN-2
CAS Number 16673-34-0 Molecular Weight 368.835
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C16H17ClN2O4S Melting Point 209-214 °C
MSDS Chinese USA Flash Point N/A

 Use of NLRP3-IN-2


NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism[1].

 Names

Name 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide
Synonym More Synonyms

 NLRP3-IN-2 Biological Activity

Description NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism[1].
Related Catalog
In Vivo NLRP3-IN-2 is well tolerated with no effects on the glucose levels in vivo[1]. NLRP3-IN-2 (100 mg/kg) treatment in a model of AMI due to ischemia+reperfusion significantly inhibits the activity of inflammasome (caspase-1) in the heart by 90% (P<0.01) and reduced infarct size, measured at pathology (by >40%, P<0.01) and with troponin I levels (by >70%, P<0.01) [1]. Animal Model: Experimental acute myocardial infarction (AMI) model in mice[1]. Dosage: 100 mg/kg. Administration: Intraperitoneal administration 30 minutes prior to surgery, then every 6 hours for 3 additional doses. Result: Led to a significant >90% reduction in caspase-1 activity (reflective of the formation of an active inflammasome) in the heart tissue measured 24 hours after ischemia. Led to a significant reduction in the infarct size measured with TTC (>40% reduction) or troponin I levels (>70% reduction) when compared with vehicle alone.
References

[1]. Carlo Marchetti, et al. A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J Cardiovasc Pharmacol. 2014 Apr;63(4):316-322.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 209-214 °C
Molecular Formula C16H17ClN2O4S
Molecular Weight 368.835
Exact Mass 368.059753
PSA 106.87000
LogP 1.74
Index of Refraction 1.598
Storage condition Refrigerator

 Safety Information

Hazard Codes T
Risk Phrases R23/24/25
Safety Phrases S26-S36-S36/37-S22
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2935009090

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles3

More Articles
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse.

J. Cardiovasc. Pharmacol. 63(4) , 316-22, (2014)

The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3 inhibitory activity in vitr...

Trendelenburg G.

J. Cereb. Blood Flow Metab. , (2014)

Reply to Letter Regarding Article," NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction. Takahashi M.

Int. Heart J. 55(4) , 380, (2014)

 Synonyms

5-chloro-2-methoxy-N-[2-(4-sulphamoylphenyl)ethyl]benzamide
Benzamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy-
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
4-[2-(5-chloro-2-methoxy-benzamide)ethyl]-benzenesulphonamide
EINECS 240-722-5
5-Chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide
MFCD00193756
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