Adefovir Dipivoxil

Modify Date: 2024-01-02 06:37:33

Adefovir Dipivoxil Structure
Adefovir Dipivoxil structure
 Common Name Adefovir Dipivoxil
CAS Number 142340-99-6 Molecular Weight 501.470
Density 1.4±0.1 g/cm3 Boiling Point 641.0±65.0 °C at 760 mmHg
Molecular Formula C20H32N5O8P Melting Point 98-102ºC
MSDS Chinese USA Flash Point 341.5±34.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Adefovir Dipivoxil


Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].

 Names

Name Adefovir dipivoxil
Synonym More Synonyms

 Adefovir Dipivoxil Biological Activity

Description Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].
Related Catalog
References

[1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16.

[2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73.

[3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38.

[4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 641.0±65.0 °C at 760 mmHg
Melting Point 98-102ºC
Molecular Formula C20H32N5O8P
Molecular Weight 501.470
Flash Point 341.5±34.3 °C
Exact Mass 501.198853
PSA 176.79000
LogP 2.45
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.569
Storage condition −20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R20/21/22
Safety Phrases 36/37
RIDADR NONH for all modes of transport

 Synthetic Route

Chloromethyl pivalate structure

Chloromethyl pi...

CAS#:18997-19-8

Adefovir structure

Adefovir

CAS#:106941-25-7

~75%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: WO2010/110506 A1, ; Page/Page column 7 ;
N4-dimethylaminomethyledino-9-(2-phosphonomethoxyethyl)adenine di(pivaloyloxymethyl) ester structure

N4-dimethylamin...

CAS#:922494-99-3

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: WO2007/13085 A1, ; Page/Page column 10-11 ;
Chloromethyl pivalate structure

Chloromethyl pi...

CAS#:18997-19-8

9-(2-Diisopanoxyphosphonylmethoxyethyl)adenine structure

9-(2-Diisopanox...

CAS#:116384-53-3

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: European Journal of Medicinal Chemistry, , vol. 63, p. 869 - 881
Chloromethyl pivalate structure

Chloromethyl pi...

CAS#:18997-19-8

Adefovir structure

Adefovir

CAS#:106941-25-7

~%

9-[2-({bis[(pivaloyloxy)methoxy]phosphinyl}methoxy)ethyl]-6-[(hydroxymethyl)amino]purine structure

9-[2-({bis[(piv...

CAS#:323201-04-3

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: EP2330107 A2, ; Page/Page column 6 ;
Iodomethyl pivalate structure

Iodomethyl pivalate

CAS#:53064-79-2

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: Journal of Medicinal Chemistry, , vol. 39, # 25 p. 4958 - 4965
N6-(4-monomethoxytrityl)-9-(2-phosphonomethoxyethyl)adenine structure

N6-(4-monometho...

CAS#:153235-86-0

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: Journal of Medicinal Chemistry, , vol. 39, # 25 p. 4958 - 4965
6H-Purin-6-imine, 1,7-dihydro- (9CI) structure

6H-Purin-6-imin...

CAS#:66224-66-6

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: US2012/238753 A1, ;
9-(2-Diisopanoxyphosphonylmethoxyethyl)adenine structure

9-(2-Diisopanox...

CAS#:116384-53-3

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: US2012/238753 A1, ;
2-(6-amino-9H-purin-9-yl)ethanol structure

2-(6-amino-9H-p...

CAS#:707-99-3

~%

Adefovir Dipivoxil Structure

Adefovir Dipivoxil

CAS#:142340-99-6

Literature: European Journal of Medicinal Chemistry, , vol. 63, p. 869 - 881

 Articles37

More Articles
Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.

J. Pharm. Sci. 104(3) , 1056-64, (2015)

The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal followin...

De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.

World J. Gastroenterol. 19(37) , 6278-83, (2013)

To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total...

Discovering novel direct acting antiviral agents for HBV using in silico screening.

Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015)

The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel ...

 Synonyms

9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine
BIS POM PMEA
ADEFOVIR PIVOXIL
Adefovir Dipivoxil
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine
Hepsera
ADEFOVIR DIPVOXIL
Preveon
MFCD00869897
EINECS 200-001-8
ADEFOVIR DIPIVOLIX
Adefovir Dipivoxyl
Adefovir Dipivoxi
Adefovir Dipivoxl
Adefovir Impurity 3
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