Adefovir Dipivoxil
Names
[ CAS No. ]:
142340-99-6
[ Name ]:
Adefovir Dipivoxil
[Synonym ]:
9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine
BIS POM PMEA
ADEFOVIR PIVOXIL
Adefovir Dipivoxil
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine
Hepsera
ADEFOVIR DIPVOXIL
Preveon
MFCD00869897
EINECS 200-001-8
ADEFOVIR DIPIVOLIX
Adefovir Dipivoxyl
Adefovir Dipivoxi
Adefovir Dipivoxl
Adefovir Impurity 3
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
641.0±65.0 °C at 760 mmHg
[ Melting Point ]:
98-102ºC
[ Molecular Formula ]:
C20H32N5O8P
[ Molecular Weight ]:
501.470
[ Flash Point ]:
341.5±34.3 °C
[ Exact Mass ]:
501.198853
[ PSA ]:
176.79000
[ LogP ]:
2.45
[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C
[ Index of Refraction ]:
1.569
[ Storage condition ]:
−20°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
36/37
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Pharm. Sci. 104(3) , 1056-64, (2015)
The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal followin...
De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.World J. Gastroenterol. 19(37) , 6278-83, (2013)
To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total...
Discovering novel direct acting antiviral agents for HBV using in silico screening.Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015)
The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel ...