Adefovir Dipivoxil
Adefovir Dipivoxil structure
|
Common Name | Adefovir Dipivoxil | ||
|---|---|---|---|---|
| CAS Number | 142340-99-6 | Molecular Weight | 501.470 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 641.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C20H32N5O8P | Melting Point | 98-102ºC | |
| MSDS | Chinese USA | Flash Point | 341.5±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.
J. Pharm. Sci. 104(3) , 1056-64, (2015) The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal following the dehydration of AD dihydrate was manipulated by alteri... |
|
|
De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.
World J. Gastroenterol. 19(37) , 6278-83, (2013) To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total of 120 naïve patients with HBV-related decompensated cirrh... |
|
|
Discovering novel direct acting antiviral agents for HBV using in silico screening.
Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015) The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel anti-viral agents for HBV-reverse transcriptase (HBV-RT). W... |
|
|
Influence of the basal core promoter and precore mutation on replication of hepatitis B virus and antiviral susceptibility of different genotypes.
J. Med. Virol. 87(4) , 601-8, (2015) Mutations in the basal core promoter (BCP) and precore (PC) regions of the hepatitis B virus (HBV) are more common in genotypes B and C than in genotype A, suggesting that these mutations might affect replication competency depending on genotype. The purpose ... |
|
|
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.
J. Am. Soc. Nephrol. 11 , 383-393, (2000) The transport of organic anions in proximal convoluted tubules plays an essential role in the active secretion of a variety of small molecules by the kidney. In addition to other anionic substrates, the human renal organic anion transporter 1 (hOATI) is capab... |
|
|
Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.
PLoS ONE 7(5) , e37724, (2012) To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase; eig... |
|
|
[Lamivudine, adefovir dipivoxil].
Nihon Rinsho. 69 Suppl 4 , 492-7, (2011)
|
|
|
Lamivudine or adefovir dipivoxil alone or combined with immunoglobulin for preventing hepatitis B recurrence after liver transplantation.
Cochrane Database Syst. Rev. (7) , CD006005, (2010) Recurrence of hepatitis B virus (HBV) infection in the liver graft is a grave complication following liver transplantation for HBV cirrhosis. Hepatitis B immunoglobulin (HBIg) seems effective in increasing survival after liver transplantation. HBIg and anti-v... |
|
|
Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma.
Cochrane Database Syst. Rev. (12) , CD008713, (2011) Hepatocellular carcinoma (HCC) is a significant cause of death, especially in Asia and sub-Saharan Africa. Removal of the cancer through surgery or other techniques is considered the first-line therapy in early HCC, but relapse of HCC is the main postoperativ... |
|
|
Comparative meta-analysis of adefovir dipivoxil monotherapy and combination therapy of adefovir dipivoxil and lamivudine for lamivudine-resistant chronic hepatitis B.
Int. J. Infect. Dis. 16(3) , e152-8, (2012) The aim of the current study was to compare the effectiveness of adefovir dipivoxil (ADV) monotherapy with that of combination ADV and lamivudine (LAM) therapy in the treatment of LAM-resistant chronic hepatitis B (CHB).Publications on the effectiveness of AD... |