DELAVIRDINE MESYLATE

Names

[ Name ]:
DELAVIRDINE MESYLATE

[Synonym ]:
DELAVIRDINE, MESYLATE
N-{2-[(4-{3-[(1-methylethyl)amino]pyridin-2-yl}piperazin-1-yl)carbonyl]-1H-indol-5-yl}methanesulfonamide methanesulfonate
N-[2-({4-[3-(Isopropylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide methanesulfonate (1:1)
Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, methanesulfonate (1:1)
1-(3-(Isopropylamino)-2-pyridyl)-4-((5-methanesulfonamidoindol-2-yl)carbonyl)piperazine monomethanesulfonate
acide méthanesulfonique - N-{2-[(4-{3-[(1-méthyléthyl)amino]pyridin-2-yl}pipérazin-1-yl)carbonyl]-1H-indol-5-yl}méthanesulfonamide (1:1)
delavirdine mesilate [INN_en]
piperazine, 1-[3-[(1-methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-, methanesulfonate (1:1)
N-[2-({4-[3-(Isopropylamino)-2-pyridinyl]-1-piperazinyl}carbonyl)-1H-indol-5-yl]methanesulfonamide methanesulfonate (1:1)
DELAVIRDINE MESYLATE
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)-, monomethanesulfonate
Delavirdine monomethanesulfonate
Methansulfonsäure--N-{2-[(4-{3-[(1-methylethyl)amino]pyridin-2-yl}piperazin-1-yl)carbonyl]-1H-indol-5-yl}methansulfonamid(1:1)
N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide methanesulfonate (1:1)
Delavirdine (mesylate)

Biological Activity

[Description]:

Delavirdine mesylate is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor (NNRTI) of HIV-1.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

Research Areas >> Infection

[References]

[1]. Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.

[2]. Voorman RL, et al. Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6. Drug Metab Dispos. 2001 Jan;29(1):41-7.

[3]. Shelton MJ, et al. Pharmacokinetics of ritonavir and delavirdine in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2003 May;47(5):1694-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
732ºC at 760mmHg

[ Melting Point ]:
118-120ºC

[ Molecular Formula ]:
C₂₃H₃₂N₆O₆S₂

[ Molecular Weight ]:
552.667

[ Flash Point ]:
396.5ºC

[ Exact Mass ]:
552.182495

[ PSA ]:
181.56000

[ LogP ]:
4.53160

[ Vapour Pressure ]:
2.74E-21mmHg at 25°C

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

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J. Med. Chem. 53 , 4259-65, (2010)

Many organic molecules form colloidal aggregates in aqueous solution at micromolar concentrations. These aggregates promiscuously inhibit soluble proteins and are a major source of false positives in ...

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Graphical abstract

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.

Bioorg. Med. Chem. 21(7) , 2128-34, (2013)

In continuation of our efforts toward identification and optimization of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs), we have employed a structure-based bioisosterism strategy, with...