Chloromethyl pivalate
Names
[ CAS No. ]:
18997-19-8
[ Name ]:
Chloromethyl pivalate
[Synonym ]:
Methanol,chloro-,pivalate
chloromethyl trimethylacetate
Propanoic acid, 2,2-dimethyl-, chloromethyl ester
pivalic acid chloromethyl ester
POM-CL
Chloromethyl Pivalate [Amino-Protecting Agent]
Chloromethyl 2,2-dimethylpropanoate
CHLOROMETHYL PIVARATE
chloromethyl 2,2-dimethylpropionate
Pivaloxymethylchlorde
2,2-Dimethyl-propionic acid chloromethyl ester
POM
CMPV
PIVALOYLOXYMETHYL CHLORIDE
CHLORO METHYL PIVILATE
Chlormethyl-2,2-dimethylpropanoat
2,2-Dimethylpropionic Acid Chloromethyl Ester
MFCD00000884
Chloromethyl pivalate
Trimethylacetic Acid Chloromethyl Ester
EINECS 242-735-1
Adefovir Impurity 13
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
143.0±13.0 °C at 760 mmHg
[ Melting Point ]:
<-40ºC
[ Molecular Formula ]:
C6H11ClO2
[ Molecular Weight ]:
150.603
[ Flash Point ]:
40.0±0.0 °C
[ Exact Mass ]:
150.044754
[ PSA ]:
26.30000
[ LogP ]:
1.64
[ Vapour Pressure ]:
5.5±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.425
[ Storage condition ]:
Flammables area
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H302 + H312 + H332-H315-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R10;R36/37/38
[ Safety Phrases ]:
S16-S26-S36-S41-S36/37/39
[ RIDADR ]:
UN 3272 3/PG 3
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
2915600000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2915900090
[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%
Articles
Synthesis 44(16) , doi:10.1055/s-0031-1289791, (2012)
A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy, is repor...
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.Antiviral Res. 19(3) , 267-73, (1992)
9-(2-Phosphonylmethoxyethyl)adenine (PMEA; 1) was acylated with chloromethyl pivalate to afford bis(pivaloyloxymethyl) PMEA (2). The ester prodrug demonstrated enhanced in vitro potency against HSV-2 ...
An efficient method for the synthesis of sulbactam pivoxil.Il Farmaco 55(2) , 134-5, (2000)
Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting...