pivampicillin

Names

[ Name ]:
pivampicillin

[Synonym ]:
Pivampicillin
2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Pivaloyloxymethyl ampicillinate
Pivampicilline
Pondocillin
Pivampicilina
Pivampicillinum
Pivaloylampicillin
Ampicillin pivaloyloxymethyl ester

Biological Activity

[Description]:

Pivampicillin is a penicillin antibiotic. Pivampicillin is a prodrug of Ampicillin (HY-B0522)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Shi CK, et, al. Bactericidal composition and application thereof. CN109568323A.

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
679ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₉N₃O₆S

[ Molecular Weight ]:
463.55

[ Flash Point ]:
364.5ºC

[ Exact Mass ]:
463.17800

[ PSA ]:
153.33000

[ LogP ]:
2.35260

[ Index of Refraction ]:
1.604

[ Water Solubility ]:
Practically insoluble in water, freely soluble in methanol, soluble in anhydrous ethanol. It dissolves in dilute acids.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH8380000

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-, hydroxymethyl ester, pivalate (ester), D-(-)-

CAS REGISTRY NUMBER :: 33817-20-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H29-N3-O6-S

MOLECULAR WEIGHT :: 463.60

WISWESSER LINE NOTATION :: T45 ANV ESTJ CMVYZR& F1 F1 GVO1OVX1&1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 900 mg/kg/90D-I

TOXIC EFFECTS :: Behavioral - muscle weakness Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 68,932,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,310,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,310,1978

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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