441785-26-8

441785-26-8 structure

Name: Besifovir Dipivoxil maleate
Chemical Name: lb-80380
CAS Number: 441785-26-8
Molecular Formula: C₂₆H₃₈N₅O₁₂P
Molecular Weight: 527.50800
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2018-01-09 08:39:36
Modify Date: 2024-01-11 12:11:07
Besifovir Dipivoxil maleate (LB80380 maleate) is an oral prodrug of LB80317. Besifovir Dipivoxil maleate (LB80380 maleate) is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients in preliminary studies[1][2]

Name	lb-80380
Synonyms	({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methylphosphonic acid dipivoxyl 2,2-Dimethyl-propionic acid [1-(2-amino-purin-9-ylmethyl)-cyclopropoxymethyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester 3-[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]-8,8-dimethyl-3,7-dioxo-2,4,6-trioxa-3λ5-phosphanon-1-yl-pivalate 9-[1-(phosphonomethoxycyclopropyl)methyl]-6-deoxyguanine 3-[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]-8,8-dimethyl-3,7-dioxo-2,4,6-trioxa-3λ5-phosphanon-1-yl pivalate

Description	Besifovir Dipivoxil maleate (LB80380 maleate) is an oral prodrug of LB80317. Besifovir Dipivoxil maleate (LB80380 maleate) is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients in preliminary studies[1][2]
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
References	[1]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83. [2]. Lai CL, et al. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2014 Jun;63(6):996-1004.