ML 289

Modify Date: 2025-08-29 15:46:12

ML 289 structure	Common Name	ML 289
	CAS Number	1382481-79-9	Molecular Weight	349.423
	Density	1.2±0.1 g/cm3	Boiling Point	557.0±35.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₃NO₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	290.7±25.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of ML 289

ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1].

Name	[(3R)-3-(Hydroxymethyl)-1-piperidinyl]{4-[(4-methoxyphenyl)ethyny l]phenyl}methanone
Synonym	More Synonyms

Description	ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR3:0.66 μM (IC50)
In Vitro	ML289 (VU0463597) is a CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) negative allosteric modulator probe[1].
References	[1]. Sheffler DJ, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012;22(12):3921-3925.

Density	1.2±0.1 g/cm3
Boiling Point	557.0±35.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₃NO₃
Molecular Weight	349.423
Flash Point	290.7±25.9 °C
Exact Mass	349.167786
PSA	49.77000
LogP	2.70
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.628
Storage condition	-20°C

ML 289 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xn
RIDADR	NONH for all modes of transport

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Literature: Sheffler, Douglas J.; Wenthur, Cody J.; Bruner, Joshua A.; Carrington, Sheridan J.S.; Vinson, Paige N.; Gogi, Kiran K.; Blobaum, Anna L.; Morrison, Ryan D.; Vamos, Mitchell; Cosford, Nicholas D.P.; Stauffer, Shaun R.; Scott Daniels; Niswender, Colleen M.; Jeffrey Conn; Lindsley, Craig W. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3921 - 3925

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Methanone, [(3R)-3-(hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-

VU0463597 [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone

[(3R)-3-(Hydroxymethyl)-1-piperidinyl]{4-[(4-methoxyphenyl)ethynyl]phenyl}methanone

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ML 289

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ML 289 Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.