1382481-79-9
1382481-79-9 structure
- Name: ML 289
- Chemical Name: [(3R)-3-(Hydroxymethyl)-1-piperidinyl]{4-[(4-methoxyphenyl)ethyny l]phenyl}methanone
- CAS Number: 1382481-79-9
- Molecular Formula: C22H23NO3
- Molecular Weight: 349.423
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2017-12-06 12:02:30
- Modify Date: 2025-08-29 15:46:12
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ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1].
| Name | [(3R)-3-(Hydroxymethyl)-1-piperidinyl]{4-[(4-methoxyphenyl)ethyny l]phenyl}methanone |
|---|---|
| Synonyms |
Methanone, [(3R)-3-(hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-
VU0463597 [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone [(3R)-3-(Hydroxymethyl)-1-piperidinyl]{4-[(4-methoxyphenyl)ethynyl]phenyl}methanone |
| Description | ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. |
|---|---|
| Related Catalog | |
| Target |
mGluR3:0.66 μM (IC50) |
| In Vitro | ML289 (VU0463597) is a CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) negative allosteric modulator probe[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 557.0±35.0 °C at 760 mmHg |
| Molecular Formula | C22H23NO3 |
| Molecular Weight | 349.423 |
| Flash Point | 290.7±25.9 °C |
| Exact Mass | 349.167786 |
| PSA | 49.77000 |
| LogP | 2.70 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.628 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
