ML 347

Modify Date: 2024-01-11 12:12:29

ML 347 structure	Common Name	ML 347
	CAS Number	1062368-49-3	Molecular Weight	352.389
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₆N₄O	Melting Point	209-210℃
	MSDS	Chinese USA	Flash Point	N/A

Use of ML 347

ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.IC50 value:Target: ALK1/ALK2ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against allthe other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM).

Name	ml347
Synonym	More Synonyms

Description	ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.IC50 value:Target: ALK1/ALK2ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against allthe other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM).
Related Catalog	Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor Research Areas >> Cancer
References	[1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

Density	1.3±0.1 g/cm3
Melting Point	209-210℃
Molecular Formula	C₂₂H₁₆N₄O
Molecular Weight	352.389
Exact Mass	352.132416
PSA	52.31000
LogP	2.63
Index of Refraction	1.695
Storage condition	-20℃

RIDADR	3077

Quinoline, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

DC Chemicals Limited
China
Product Name: ML347
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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ML 347

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