THP-PEG4-OH

Modify Date: 2024-01-02 23:48:22

THP-PEG4-OH Structure
THP-PEG4-OH structure
Common Name THP-PEG4-OH
CAS Number 128660-97-9 Molecular Weight 278.342
Density 1.1±0.1 g/cm3 Boiling Point 394.0±42.0 °C at 760 mmHg
Molecular Formula C13H26O6 Melting Point N/A
MSDS N/A Flash Point 192.1±27.9 °C

 Use of THP-PEG4-OH


THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol
Synonym More Synonyms

 THP-PEG4-OH Biological Activity

Description THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 394.0±42.0 °C at 760 mmHg
Molecular Formula C13H26O6
Molecular Weight 278.342
Flash Point 192.1±27.9 °C
Exact Mass 278.172943
LogP -1.46
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.467

 Synonyms

Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-
2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol