26150-06-1
26150-06-1 structure
- Name: Acryloyl-PEG4-OH
- Chemical Name: 2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol
- CAS Number: 26150-06-1
- Molecular Formula: C11H22O5
- Molecular Weight: 234.28900
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-10-02 22:38:54
- Modify Date: 2024-01-03 16:47:21
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Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol |
|---|---|
| Synonyms |
2-(2-(2-(2-allyloxy-ethoxy)-ethoxy)-ethoxy)-ethanol
2-(2-(2-(2-allyloxyethoxy)ethoxy)ethoxy)ethan-1-ol 2-{2-[2-(-allyloxyethoxy)ethoxy]ethoxy}ethanol 3,6,9,12-Tetraoxapentadec-14-en-1-ol tetraethylene glycol allyl ether tetraethylene glycol monoallyl ether |
| Description | Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C11H22O5 |
|---|---|
| Molecular Weight | 234.28900 |
| Exact Mass | 234.14700 |
| PSA | 57.15000 |
| LogP | 0.23110 |
|
~74%
26150-06-1 |
| Literature: Xu, William Z.; Zhang, Xinyue; Kadla, John F. Biomacromolecules, 2012 , vol. 13, # 2 p. 350 - 357 |
|
~%
26150-06-1 |
| Literature: ISIS INNOVATION LIMITED Patent: US2012/178913 A1, 2012 ; |
|
~24%
26150-06-1 |
| Literature: Petersen, Svea; Alonso, Jose Maria; Specht, Alexandre; Duodu, Portia; Goeldner, Maurice; Del Campo, Aranzazu Angewandte Chemie - International Edition, 2008 , vol. 47, # 17 p. 3192 - 3195 |
|
~50%
26150-06-1 |
| Literature: Breed; Ramsden; Brown Canadian Journal of Chemistry, 2001 , vol. 79, # 5-6 p. 1049 - 1057 |
|
~39%
26150-06-1 |
| Literature: Ali-Adib, Ziad; Bomben, Andrea; Davis, Frank; Hodge, Philip; Tundo, Pietro; Valli, Ludovico Journal of Materials Chemistry, 1996 , vol. 6, # 1 art. no. 5/02127H, p. 15 - 22 |
|
~%
26150-06-1 |
| Literature: Riemschneider; Koetzsch Monatshefte fuer Chemie, 1959 , vol. 90, p. 787,788,790 |
| Precursor 3 | |
|---|---|
| DownStream 3 | |
![4-methylbenzenesulfonic acid,2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol structure](https://www.chemsrc.com/caspic/438/98269-27-3.png)