Mal-PEG4-OH

Modify Date: 2025-08-25 10:13:08

Mal-PEG4-OH Structure
Mal-PEG4-OH structure
Common Name Mal-PEG4-OH
CAS Number 1421933-37-0 Molecular Weight 273.282
Density 1.2±0.1 g/cm3 Boiling Point 427.9±35.0 °C at 760 mmHg
Molecular Formula C12H19NO6 Melting Point N/A
MSDS N/A Flash Point 212.6±25.9 °C

 Use of Mal-PEG4-OH


Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-(2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}ethyl)-1H-pyrrole-2,5-dione
Synonym More Synonyms

 Mal-PEG4-OH Biological Activity

Description Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 427.9±35.0 °C at 760 mmHg
Molecular Formula C12H19NO6
Molecular Weight 273.282
Flash Point 212.6±25.9 °C
Exact Mass 273.121246
LogP -1.61
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.512

 Synonyms

1-(2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}ethyl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-
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