SIRT-IN-3

Modify Date: 2025-08-24 18:00:20

SIRT-IN-3 structure	Common Name	SIRT-IN-3
	CAS Number	1211-19-4	Molecular Weight	212.24700
	Density	1.218g/cm3	Boiling Point	413.3ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	203.8ºC

Use of SIRT-IN-3

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].

Name	2-anilinobenzamide
Synonym	More Synonyms

Description	SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
In Vitro	SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1].
References	[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62.

Density	1.218g/cm3
Boiling Point	413.3ºC at 760 mmHg
Molecular Formula	C₁₃H₁₂N₂O
Molecular Weight	212.24700
Flash Point	203.8ºC
Exact Mass	212.09500
PSA	55.12000
LogP	3.30240
Vapour Pressure	4.84E-07mmHg at 25°C
Index of Refraction	1.663

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV2340485

CHEMICAL NAME :: Benzamide, o-anilino-

CAS REGISTRY NUMBER :: 1211-19-4

BEILSTEIN REFERENCE NO. :: 0782669

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H12-N2-O

MOLECULAR WEIGHT :: 212.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,703,1971

HS Code	2924299090

Bromobenzene

CAS#:108-86-1

Benzenecarboxim...

CAS#:28144-70-9

~80%

SIRT-IN-3

CAS#:1211-19-4

Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655

Bromobenzene

CAS#:108-86-1

Benzenecarboxim...

CAS#:28144-70-9

~0%

SIRT-IN-3

CAS#:1211-19-4

2'-aminobenzanilide

CAS#:4424-17-3

Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655

N-Phenylanthran...

CAS#:91-40-7

~58%

SIRT-IN-3

CAS#:1211-19-4

Literature: Maruyama; Kawata; Ono; Nishizawa; Ito; Inoue Bioscience, biotechnology, and biochemistry, 2001 , vol. 65, # 8 p. 1761 - 1765

Benzoyl chlorid...

CAS#:57623-73-1

SIRT-IN-3

CAS#:1211-19-4

Literature: ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG Patent: WO2008/52742 A1, 2008 ; Location in patent: Page/Page column 17; Sheet 1 ;

2-Anilinobenzoi...

CAS#:35708-19-1

SIRT-IN-3

CAS#:1211-19-4

Literature: Goodman; Arbiter; Powell Journal of the American Chemical Society, 1933 , vol. 55, p. 4294,4297, 4298

1-PHENYL-1H-BEN...

CAS#:20877-86-5

SIRT-IN-3

CAS#:1211-19-4

Literature: Coyne,W.E.; Cusic,J.W. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1208 - 1213

Precursor 6
CAS#:108-86-1 Bromobenzene CAS#:28144-70-9 Benzenecarboxim... CAS#:91-40-7 N-Phenylanthran... CAS#:57623-73-1 Benzoyl chlorid...
CAS#:35708-19-1 2-Anilinobenzoi... CAS#:20877-86-5 1-PHENYL-1H-BEN...
DownStream 4
CAS#:20877-84-3 2-(aminomethyl)... CAS#:17583-00-5 Benzonitrile, 2... CAS#:66478-79-3 2-(chloromethyl... CAS#:66491-84-7 ethyl 4-oxo-1-p...

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-phenyl-anthranilic acid amide

Benzamide,o-anilino

N-Phenyl-anthranilsaeure-amid

Anilinobenzamide

N-phenylanthranylamide

N-phenylanthranilamide

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SIRT-IN-3
Price: Check
Purity: 98.0%
Delivery: 10 Day
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DC Chemicals Limited
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzamide,2-(phenylamino)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: SIRT-IN-3
Price: ￥Inquiry/10g ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/5g
Purity: 97.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

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Price: ￥550/10 mM * 1 mL in DMSO

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