SIRT-IN-1
Modify Date: 2025-11-25 22:02:59
SIRT-IN-1 structure
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Common Name | SIRT-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1431411-60-7 | Molecular Weight | 389.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H27N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SIRT-IN-1SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. |
| Name | SIRT-IN-1 |
|---|
| Description | SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. |
|---|---|
| Related Catalog | |
| Target |
SIRT1:15 nM (IC50) SIRT2:10 nM (IC50) SIRT3:33 nM (IC50) |
| In Vitro | SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1]. |
| References |
| Molecular Formula | C19H27N5O2S |
|---|---|
| Molecular Weight | 389.52 |
| InChIKey | NSPKBHVNVJWICU-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 |