Tropine

Modify Date: 2025-08-21 19:19:05

Tropine structure	Common Name	Tropine
	CAS Number	120-29-6	Molecular Weight	141.211
	Density	1.1±0.1 g/cm3	Boiling Point	233.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₅NO	Melting Point	50-60 °C(lit.)
	MSDS	USA	Flash Point	112.5±14.5 °C

Use of Tropine

Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent[1]. Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine[2].

Name	tropine
Synonym	More Synonyms

Description	Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent[1]. Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Grynkiewicz G, et al. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.Pharmacol Rep. 2008 Jul-Aug;60(4):439-63. [2]. Richter U, et al. Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures.J Exp Bot. 2005 Feb;56(412):645-52. Epub 2005 Jan 10.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Grynkiewicz G, et al. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.Pharmacol Rep. 2008 Jul-Aug;60(4):439-63.

[2]. Richter U, et al. Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures.J Exp Bot. 2005 Feb;56(412):645-52. Epub 2005 Jan 10.

Density	1.1±0.1 g/cm3
Boiling Point	233.0±0.0 °C at 760 mmHg
Melting Point	50-60 °C(lit.)
Molecular Formula	C₈H₁₅NO
Molecular Weight	141.211
Flash Point	112.5±14.5 °C
Exact Mass	141.115356
PSA	23.47000
LogP	-0.10
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.526
Storage condition	2-8°C
Water Solubility	100 g/L (20 ºC)

Tropine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3875000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol

CAS REGISTRY NUMBER :: 120-29-6

BEILSTEIN REFERENCE NO. :: 0080188

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H15-N-O

MOLECULAR WEIGHT :: 141.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 139 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/22
Safety Phrases	S22-S24/25
RIDADR	1544
WGK Germany	3
RTECS	YM3875000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

Precursor 9
CAS#:1234788-77-2 tropine-N-oxide... CAS#:50-00-0 Formaldehyde CAS#:538-09-0 8-Aza-bicyclo[3... CAS#:115522-58-2 6-(benzyloxy)-1...
CAS#:115522-57-1 1β-acetoxy-4β-c... CAS#:115522-45-7 1β-acetoxy-4α-(... CAS#:51-55-8 Atropine CAS#:93713-44-1 (1R,3r,5S)-3-hy...
CAS#:532-24-1 Tropinone
DownStream 10
CAS#:107007-94-3 8-Methyl-8-azab... CAS#:538-09-0 8-Aza-bicyclo[3... CAS#:50626-97-6 8-Azabicyclo[3.... CAS#:40796-97-2 MDL 72222
CAS#:3736-36-5 endo-8-Methyl-8... CAS#:35130-97-3 ENDO-8-METHYL-8... CAS#:51-55-8 Atropine CAS#:80830-76-8 1,2-bis(3-α-hyd...
CAS#:464-72-2 Benzopinacole CAS#:80830-75-7 8-(2-hydroxy-2,...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Tropine dehydrogenase: purification, some properties and an evaluation of its role in the bacterial metabolism of tropine.

Biochem. J. 307 ( Pt 2) , 603-8, (1995)

Tropine dehydrogenase was induced by growth of Pseudomonas AT3 on atropine, tropine or tropinone. It was NADP(+)-dependent and gave no activity with NAD+. The enzyme was very unstable but a rapid puri...

The metabolism of atropine in man.

J. Pharm. Pharmacol. 38(10) , 781-4, (1986)

A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal vo...

Determination of nitrogen-15 isotope fractionation in tropine: evaluation of extraction protocols for isotope ratio measurement by isotope ratio mass spectrometry.

Rapid Commun. Mass Spectrom. 23(24) , 4031-7, (2009)

N-Demethylation of tropine is an important step in the degradation of this compound and related metabolites. With the purpose of understanding the reaction mechanism(s) involved, it is desirable to me...

(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol

8-Methyl-8-azabicyclo[3.2.1]octan-3-ol

Tropine

endo-Tropanol

TROPAN-3ALPHA-OL

3alpha-Tropanol

8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-

EINECS 204-384-2

MFCD00005551

8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, (1R,5S)-

endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol

tropinol

3-TROPANOL

TROPANOL

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China
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China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tropine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Tropine

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