Tropine
Tropine structure
|
Common Name | Tropine | ||
|---|---|---|---|---|
| CAS Number | 120-29-6 | Molecular Weight | 141.211 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 233.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H15NO | Melting Point | 50-60 °C(lit.) | |
| MSDS | USA | Flash Point | 112.5±14.5 °C | |
|
Tropine dehydrogenase: purification, some properties and an evaluation of its role in the bacterial metabolism of tropine.
Biochem. J. 307 ( Pt 2) , 603-8, (1995) Tropine dehydrogenase was induced by growth of Pseudomonas AT3 on atropine, tropine or tropinone. It was NADP(+)-dependent and gave no activity with NAD+. The enzyme was very unstable but a rapid purification procedure using affinity chromatography that gave ... |
|
|
The metabolism of atropine in man.
J. Pharm. Pharmacol. 38(10) , 781-4, (1986) A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal volunteer is proposed. Noratropine (24%), atropine-N-oxide (e... |
|
|
Determination of nitrogen-15 isotope fractionation in tropine: evaluation of extraction protocols for isotope ratio measurement by isotope ratio mass spectrometry.
Rapid Commun. Mass Spectrom. 23(24) , 4031-7, (2009) N-Demethylation of tropine is an important step in the degradation of this compound and related metabolites. With the purpose of understanding the reaction mechanism(s) involved, it is desirable to measure the 15N kinetic isotope effects (KIEs), which can be ... |
|
|
Effect of tropine derivatives, antimuscarinic agents, on the growth of Bombyx mori larvae.
Biosci. Biotechnol. Biochem. 62(10) , 2046-8, (1998) A number of atropine analogs were synthesized and their effects on larval growth of the silkworm, Bombyx mori, were investigated by both topical application and dietary administration. Among the tested compounds, 8-methyl-8-azabicyclo[3.2.1]octan-3 alpha-ol 2... |
|
|
Molecular cloning and catalytic characterization of a recombinant tropine biosynthetic tropinone reductase from Withania coagulans leaf.
Gene 516(2) , 238-47, (2013) Tropinone reductases (TRs) are small proteins belonging to the SDR (short chain dehydrogenase/reductase) family of enzymes. TR-I and TR-II catalyze the conversion of tropinone into tropane alcohols (tropine and pseudotropine, respectively). The steps are inte... |
|
|
Interference of mandelic acid with the determination of homatropine hydrobromide by second-order derivative spectroscopy.
J. Pharm. Biomed. Anal. 12(9) , 1199-203, (1994)
|
|
|
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.
Bioorg. Med. Chem. 17(19) , 6872-8, (2009) Heteroaromatic carboxylic esters of (nor)tropine were synthesized. Tropine esters displaced [(3)H]strychnine binding to glycine receptors of rat spinal cord with low Hill slopes. Two-site displacement resulted in nanomolar IC(50,1) and micromolar IC(50,2) val... |
|
|
Induction of tropane alkaloid formation in transformed root cultures of Brugmansia suaveolens (Solanaceae).
Z. Naturforsch., C, J. Biosci. 59(11-12) , 863-7, (2004) Hairy root cultures of Brugmansia suaveolens were set up by infection of root tips with Agrobacterium rhizogenes. The successful transformation was confirmed by analysing rolC and virC genes using polymerase chain reaction (PCR). Hairy root cultures were empl... |
|
|
The development of ultrashort acting neuromuscular relaxant tropane derivatives.
J. Crit. Care 24(1) , 58-65, (2009) There is a need for neuromuscular relaxant (NMR) agents that are of the "nondepolarizing type" and produce rapidly developing and short-lasting skeletal muscle relaxation in anesthesiology. Many efforts have been directed to produce such agents. Our research ... |
|
|
Role of 5-HT3 receptors in the mechanisms of central pain syndrome.
Bull. Exp. Biol. Med. 135(6) , 552-5, (2003) Electrophysiological and behavioral studies showed that spinal 5-HT3 receptors are involved in the regulation of pain sensitivity in rats. Intrathecal administration of the 5-HT3 receptor antagonist tropine (200 microg) produced allodynia, reduced the thresho... |