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Related CAS#:
1508-75-4 57322-49-3
2673270-13-6 92934-63-9
92934-64-0 56598-62-0
529-64-6

1508-75-4

1508-75-4 structure
1508-75-4 structure
  • Name: Tropicamide
  • Chemical Name: Tropicamide
  • CAS Number: 1508-75-4
  • Molecular Formula: C17H20N2O2
  • Molecular Weight: 284.353
  • Catalog: API Special medicine Ophthalmic medication
  • Create Date: 2018-08-23 18:52:31
  • Modify Date: 2024-01-02 10:36:28
  • Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].
Name Tropicamide
Synonyms N-Ethyl-N-(g-picolyl)tropamide
8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
Tropine
endo-Tropanol
TROPAN-3ALPHA-OL
3alpha-Tropanol
N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-
N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
N-Ethyl-N-(4-pyridylmethyl)tropamide
N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide
Benzeneacetamide, N-ethyl-α-(hydroxymethyl)-N-(4-pyridinylmethyl)-
EINECS 216-140-2
Tropicamide
Mydriacyl
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683,Tropicamide
UNII:N0A3Z5XTC6
endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
tropinol
MFCD00058580
3-TROPANOL
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683
TROPANOL
Description Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].
Related Catalog
References

[1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15.

[2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.
Density 1.2±0.1 g/cm3
Boiling Point 492.8±45.0 °C at 760 mmHg
Melting Point 98 °C
Molecular Formula C17H20N2O2
Molecular Weight 284.353
Flash Point 251.8±28.7 °C
Exact Mass 284.152466
PSA 53.43000
LogP 1.15
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.586
Storage condition 2-8°C
Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1487860
CHEMICAL NAME :
Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-
CAS REGISTRY NUMBER :
1508-75-4
BEILSTEIN REFERENCE NO. :
0285563
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H20-N2-O2
MOLECULAR WEIGHT :
284.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
865 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
872 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
565 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
695 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
665 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2832 No. of Facilities: 112 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4368 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2832 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 11614 (estimated) No. of Female Employees: 11545 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H317-H319-H335
Precautionary Statements P261-P280-P301 + P312 + P330-P305 + P351 + P338
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22;R36/37/38;R42/43
Safety Phrases S22-S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CY1487860
HS Code 2933399090
33403-97-3 structure

33403-97-3

~%

1508-75-4 structure

1508-75-4
Literature: DE960634 , ;
14510-37-3 structure

14510-37-3
33403-97-3 structure

33403-97-3

~%

1508-75-4 structure

1508-75-4
Literature: DE960634 , ;
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 1508-75-4 | Chemsrc address: https://www.chemsrc.com/en/baike/1150762.html

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