Hyoscyamine

Modify Date: 2024-01-02 16:53:02

Hyoscyamine structure	Common Name	Hyoscyamine
	CAS Number	101-31-5	Molecular Weight	289.369
	Density	1.2±0.1 g/cm3	Boiling Point	429.8±45.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₃NO₃	Melting Point	108.5ºC
	MSDS	N/A	Flash Point	213.7±28.7 °C

Use of Hyoscyamine

L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.Target: mAChRHyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care [1].

Name	(S)-atropine
Synonym	More Synonyms

Description	L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.Target: mAChRHyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care [1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. http://www.drugbank.ca/drugs/DB00424

Density	1.2±0.1 g/cm3
Boiling Point	429.8±45.0 °C at 760 mmHg
Melting Point	108.5ºC
Molecular Formula	C₁₇H₂₃NO₃
Molecular Weight	289.369
Flash Point	213.7±28.7 °C
Exact Mass	289.167786
PSA	49.77000
LogP	1.53
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.581
Storage condition	2-8°C

Hyoscyamine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NH0875000

CHEMICAL NAME :: Hyoscyamine, (-)-

CAS REGISTRY NUMBER :: 101-31-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H23-N-O3

MOLECULAR WEIGHT :: 289.41

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOVYR&1Q -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1471 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 24,138,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1029 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

Hazard Codes	T+: Very toxic;
Risk Phrases	R26/28
Safety Phrases	24-45
RIDADR	UN 1544 6
WGK Germany	3
RTECS	NH0875000
HS Code	2933990090

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Precursor 7
CAS#:51-34-3 Scopolamine CAS#:114-49-8 Scopolamine hyd... CAS#:16202-15-6 (S)-Tropic acid CAS#:120-29-6 Tropine
CAS#:74-88-4 methyl iodide CAS#:3144-16-9 D-Camphorsulfon... CAS#:51-55-8 Atropine
DownStream 5
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CAS#:500-55-0 8-Methyl-8-azab...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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CYSTOSPAZ

L-Hyoscyamine

3a-Tropanyl S-(-)-Tropate

(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl-(2S)-3-hydroxy-2-phenylpropanoat

scopolamine HCl

SCOPINE TROPATE

Levsin

(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate

(S)-(-)-hyoscyamine

Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-

SCOPINE TROPATE HYDROCHLORIDE

Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (αS)-

MFCD00067306

(S)-atropine

Hyoscyamine

(-)-Hycosamine

(-)-Hyoscyamine

EINECS 202-933-0

Daturine

chlorhydratedescopolamine

Egacene

1-Tropic Acid Ester with Tropine

(-)-atropine

er),hcl

[3(S)-endo]-a-(Hydroxymethyl)benzeneacetic Acid 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester

Peptard

ScopolamineSeries

L-Tropine tropate

(2S)-(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate

1aH,5aH-Tropan-3a-ol(-)-tropate (Ester)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hyoscyamine
Price: ￥398.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: L-Hyoscyamine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-hyoscyamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Hyoscyamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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Hyoscyamine

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