Cogentin

Modify Date: 2025-08-25 17:44:49

Cogentin structure	Common Name	Cogentin
	CAS Number	86-13-5	Molecular Weight	307.42900
	Density	1.11g/cm3	Boiling Point	409ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₅NO	Melting Point	N/A
	MSDS	N/A	Flash Point	120.1ºC

Use of Cogentin

Benztropine mesylate is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].

Name	benzatropine
Synonym	More Synonyms

Description	Benztropine mesylate is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	5 μM (MDA-MB-231)
In Vitro	Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne[1]. Benztropine mesylate inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors[1]. Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination[1]. Cell Viability Assay[1] Cell Line: MDA-MB-231 Concentration: 0, 0.1, 0.625, 1.25, 2.5, 5, 10 μM Incubation Time: 72 hours Result: Inhibited cells growth of MDA-MB-231 with IC50 ~5.0 μM. Cell Viability Assay[1] Cell Line: MDA-MB-231 Concentration: 0, 1, 2, 5 μM Incubation Time: 4-6 days Result: Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.
In Vivo	Benztropine mesylate (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model[1]. Animal Model: Balb/c mice bearing 4T1 breast tumors[1] Dosage: 1.5 mg/kg Administration: Injection; 3 weeks Result: Reduced the tumor size and weight significantly without body weight changing.
References	[1]. Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022. [2]. Santosh S Kulkarni, et al. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorg Med Chem. 2006 Jun 1;14(11):3625-34.

Density	1.11g/cm3
Boiling Point	409ºC at 760 mmHg
Molecular Formula	C₂₁H₂₅NO
Molecular Weight	307.42900
Flash Point	120.1ºC
Exact Mass	307.19400
PSA	12.47000
LogP	4.35570
Index of Refraction	1.604

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3100000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropane, 3-alpha-(diphenylmethoxy)-

CAS REGISTRY NUMBER :: 86-13-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H25-N-O

MOLECULAR WEIGHT :: 307.47

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOYR&R -ALL ALPHA

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,215,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,215,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3957 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 103 (estimated) No. of Female Employees: 52 (estimated)

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Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

N-Boc-Nortropine

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Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

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Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

3α-(1-azidobenz...

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Cogentin

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Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

Bromodiphenylmethane

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Cogentin

CAS#:86-13-5

Literature: Merck and Co.Inc. Patent: US2706198 , 1952 ;

N/A

CAS#:908093-98-1

Tropine

CAS#:120-29-6

Cogentin

CAS#:86-13-5

Literature: Merck and Co.Inc. Patent: US2595405 , 1949 ;

3α-benzhydrylox...

CAS#:797763-49-6

~82%

Cogentin

CAS#:86-13-5

Literature: Pedersen, Hanne; Sinning, Steffen; Buelow, Anne; Wiborg, Ove; Falborg, Lise; Bols, Mikael Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2861 - 2869

Benaztropine

benzotropine

exo-Benztropine

tropine benzohydryl ether

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Cogentin

Use of Cogentin

Names

Cogentin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.