Sch 37370

Modify Date: 2024-01-08 21:40:59

Sch 37370 structure	Common Name	Sch 37370
	CAS Number	117796-52-8	Molecular Weight	352.85700
	Density	1.257g/cm3	Boiling Point	546.9ºC at 760mmHg
	Molecular Formula	C₂₁H₂₁ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	284.5ºC

Use of Sch 37370

N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].

Name	1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
Synonym	More Synonyms

Description	N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4.

Density	1.257g/cm3
Boiling Point	546.9ºC at 760mmHg
Molecular Formula	C₂₁H₂₁ClN₂O
Molecular Weight	352.85700
Flash Point	284.5ºC
Exact Mass	352.13400
PSA	33.20000
LogP	4.21570
Vapour Pressure	5.15E-12mmHg at 25°C
Index of Refraction	1.626
Storage condition	-20°C

Desloratadine

CAS#:100643-71-8

Acetyl chloride

CAS#:75-36-5

Sch 37370

CAS#:117796-52-8

Literature: Mu, Shuai; Xie, Xiao-Shuai; Niu, Duan; Zhang, Da-Shuai; Liu, Deng-Ke; Liu, Chang-Xiao Chinese Chemical Letters, 2013 , vol. 24, # 6 p. 531 - 534

Ethanoic anhydride

CAS#:108-24-7

Desloratadine

CAS#:100643-71-8

~81%

Sch 37370

CAS#:117796-52-8

Literature: Mezei, Tibor; Volk, Balazs; Kiraly, Imre; Simig, Gyula Organic Process Research and Development, 2008 , vol. 12, # 5 p. 855 - 859

N-tert-butyl-3-...

CAS#:32998-95-1

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

Loratadine Impu...

CAS#:31255-57-9

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

3-[2-(3-CHLORO-...

CAS#:107285-30-3

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

(1-Methyl-4-pip...

CAS#:130642-50-1

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

Loratadine

CAS#:79794-75-5

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

m-Chlorbenzyl c...

CAS#:620-20-2

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

N-Methyl Deslor...

CAS#:38092-89-6

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

Precursor 10
CAS#:100643-71-8 Desloratadine CAS#:75-36-5 Acetyl chloride CAS#:108-24-7 Ethanoic anhydride CAS#:32998-95-1 N-tert-butyl-3-...
CAS#:31255-57-9 Loratadine Impu... CAS#:107285-30-3 3-[2-(3-CHLORO-... CAS#:130642-50-1 (1-Methyl-4-pip... CAS#:79794-75-5 Loratadine
CAS#:620-20-2 m-Chlorbenzyl c... CAS#:38092-89-6 N-Methyl Deslor...
DownStream 0

N-Acetyldesloratadine

PegCNTF

RESPATADINE

Loratadine Impurity 11

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sch 37370
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Sch 37370

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