SCH 58261
Modify Date: 2024-01-08 17:33:44
SCH 58261 structure
|
Common Name | SCH 58261 | ||
|---|---|---|---|---|
| CAS Number | 160098-96-4 | Molecular Weight | 345.35800 | |
| Density | 1.54g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H15N7O | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of SCH 58261SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.target: adenosine A2A receptorIC50: 15 nM [3]in vitro: NK cells were cultured in NK cell media and preincubated with or without 1 uM SCH58261 30 min before simulation with indicated concentrations of IL-18 (R & D Systems) and IL-12p70 (Australian Biosearch) in the presence or absence of NECA (1 uM) or CGS-21680 (100 nM).[1]in vivo: it was demonstrated that the selective antagonist of the A2Areceptor, SCH58261, administered i.p. starting from the early minutes after ischemia induction, reduces ischemic brain damage and neurological deficit 24 h thereafter. vehicle-rats received saline with Tween 80 (1 %) administered (i.p.) .SCH58261 (0.01 mg/kg, i.p.), administered twice/day for 7 days [2] |
| Name | 2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
|---|---|
| Synonym | More Synonyms |
| Description | SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.target: adenosine A2A receptorIC50: 15 nM [3]in vitro: NK cells were cultured in NK cell media and preincubated with or without 1 uM SCH58261 30 min before simulation with indicated concentrations of IL-18 (R & D Systems) and IL-12p70 (Australian Biosearch) in the presence or absence of NECA (1 uM) or CGS-21680 (100 nM).[1]in vivo: it was demonstrated that the selective antagonist of the A2Areceptor, SCH58261, administered i.p. starting from the early minutes after ischemia induction, reduces ischemic brain damage and neurological deficit 24 h thereafter. vehicle-rats received saline with Tween 80 (1 %) administered (i.p.) .SCH58261 (0.01 mg/kg, i.p.), administered twice/day for 7 days [2] |
|---|---|
| Related Catalog | |
| References |
| Density | 1.54g/cm3 |
|---|---|
| Molecular Formula | C18H15N7O |
| Molecular Weight | 345.35800 |
| Exact Mass | 345.13400 |
| PSA | 100.06000 |
| LogP | 3.14010 |
| Index of Refraction | 1.807 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2934999090 |
|
~20%
SCH 58261 CAS#:160098-96-4 |
| Literature: Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171 |
|
~%
SCH 58261 CAS#:160098-96-4 |
| Literature: Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171 |
|
~%
SCH 58261 CAS#:160098-96-4 |
| Literature: Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171 |
|
~%
SCH 58261 CAS#:160098-96-4 |
| Literature: Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171 |
![5-amino-1-(β-phenylethyl)-4-[3-(2-furyl)-1,2,4-triazol-5-yl]pyrazole structure](https://www.chemsrc.com/caspic/370/159979-95-0.png)
![N-(4-imino-1-phenethyl-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)furan-2-carboxamide structure](https://www.chemsrc.com/caspic/105/162401-28-7.png)
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Psychopharmacol. Ser. 232(2) , 421-35, (2015) Several studies have suggested the inhibitory control of adenosine (A)2A receptor stimulation in cocaine-induced behavioral actions.A combination of systemic or local drug injections and in vivo neuro... |
|
|
Endothelial dysfunction impairs vascular neurotransmission in tail arteries.
Neurochem. Int. 80 , 7-13, (2015) The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact... |
|
|
Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.
J. Neuroinflammation 12 , 115, (2015) Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a degenerative disease characterized by the loss of retinal ganglion cells (RGCs). There is clinical and experimental evidence ... |
| 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine |
| 2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
| SCH58261 |
| SCH 58261 |