… of platelet-activating factor and histamine. Identification of structural requirements for dual activity of N-acyl-4-(5, 6-dihydro-11H-benzo [5, 6] cyclohepta [1, 2-b] pyridin- …

…, JK Wong, MJ Green, AK Ganguly…

Index: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

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Citation Number: 57

Abstract

A number of other mediators are also released at various stages of the allergic response. Although the physiological effects of each of these mediators are relatively well known, the exact role they each play during the response remains unclear. For example, histamine contracts smooth muscle and produces edema,'but for the most part the H1-antihistamines have been ineffective in the treatment of asthmase