Loratadine

Modify Date: 2024-01-02 11:27:58

Loratadine Structure
Loratadine structure
Common Name Loratadine
CAS Number 79794-75-5 Molecular Weight 382.883
Density 1.3±0.1 g/cm3 Boiling Point 531.3±50.0 °C at 760 mmHg
Molecular Formula C22H23ClN2O2 Melting Point 134-136°C
MSDS Chinese USA Flash Point 275.1±30.1 °C

 Use of Loratadine


Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells.

 Names

Name Loratadine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 531.3±50.0 °C at 760 mmHg
Melting Point 134-136°C
Molecular Formula C22H23ClN2O2
Molecular Weight 382.883
Flash Point 275.1±30.1 °C
Exact Mass 382.144806
PSA 42.43000
LogP 5.94
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.614
Storage condition 2-8°C
Stability Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.
Water Solubility DMSO: 26 mg/mL, soluble

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles63

More Articles
Efficient HPLC method development using structure-based database search, physico-chemical prediction and chromatographic simulation.

J. Pharm. Biomed. Anal. 104 , 49-54, (2014)

Development of a robust HPLC method for pharmaceutical analysis can be very challenging and time-consuming. In our laboratory, we have developed a new workflow leveraging ACD/Labs software tools to im...

Antihistamines modulate the integrin signaling pathway in h9c2 rat cardiomyocytes: Possible association with cardiotoxicity.

Hum. Exp. Toxicol. 34 , 796-807, (2015)

The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not w...

Reliability of computer-assisted method transfer between several column dimensions packed with 1.3-5μm core-shell particles and between various instruments.

J. Pharm. Biomed. Anal. 94 , 188-95, (2014)

In this contribution, the possibility to automatically transfer RPLC methods between different column dimensions and instruments was evaluated using commercial modelling software. The method transfer ...

 Synonyms

MFCD00672869
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
CLARATYNE
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
Ethyl-4-(8-chlor-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yliden)piperidin-1-carboxylat
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
Loratadine
Flonidan
Claritine
Loranox
CLARITIN
Tadine
Klaritin
Civeran
Clarityn
Cronopen
Lisino
11-[N-(Ethoxycarbonyl)-4-piperidylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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