Loratadine
Loratadine structure
|
Common Name | Loratadine | ||
|---|---|---|---|---|
| CAS Number | 79794-75-5 | Molecular Weight | 382.883 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 531.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H23ClN2O2 | Melting Point | 134-136°C | |
| MSDS | Chinese USA | Flash Point | 275.1±30.1 °C | |
|
Efficient HPLC method development using structure-based database search, physico-chemical prediction and chromatographic simulation.
J. Pharm. Biomed. Anal. 104 , 49-54, (2014) Development of a robust HPLC method for pharmaceutical analysis can be very challenging and time-consuming. In our laboratory, we have developed a new workflow leveraging ACD/Labs software tools to improve the performance of HPLC method development. First, we... |
|
|
Antihistamines modulate the integrin signaling pathway in h9c2 rat cardiomyocytes: Possible association with cardiotoxicity.
Hum. Exp. Toxicol. 34 , 796-807, (2015) The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of t... |
|
|
Reliability of computer-assisted method transfer between several column dimensions packed with 1.3-5μm core-shell particles and between various instruments.
J. Pharm. Biomed. Anal. 94 , 188-95, (2014) In this contribution, the possibility to automatically transfer RPLC methods between different column dimensions and instruments was evaluated using commercial modelling software. The method transfer reliability was tested with loratadine and its 7 related ph... |
|
|
Flushing, fatigue, and recurrent anaphylaxis: a delayed diagnosis of mastocytosis
Lancet 383(9928) , 1608, (2014)
|
|
|
Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall.
Fitoterapia 103 , 265-76, (2015) The current study was designed to explore the mechanism of the prokinetic activity of Gentiopicroside (Ge), from Gentiana macrophylla Pall which is widely used to strengthen gastric motility in clinic.Gastrointestinal motility disorder rats were induced by st... |
|
|
Comparative effects of terfenadine and loratadine in the treatment of hay fever.
J. Investig. Allergol. Clin. Immunol. 1(6) , 368-72, (1991) This double-blind, double-dummy, parallel-group study was undertaken in 40 patients with seasonal allergic rhinoconjunctivitis during the 1990 hay fever season. The patients were randomized and treated for seven days with either 120 mg terfenadine or 10 mg lo... |
|
|
H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?
Clin. Exp. Allergy 42(10) , 1423-9, (2012) Urticaria, and especially chronic spontaneous urticaria (CSU), is a difficult condition to treat. Consequently, clinicians need to use the best H(1)-antihistamines currently available and the pharmaceutical industries need to keep developing H(1)-antihistamin... |
|
|
Utility of 4-chloro-7-nitrobenzofurazan (NBD-CI) for the Spectrophotometric and spectrofluorometric determination of several antihistamine and antihypertensive drugs.
J. AOAC Int. 96(5) , 968-75, (2013) New, sensitive, and selective spectrophotometric and spectrofluorometric methods have been developed for determination of clemastine hydrogen fumarate (Clem), loratadine (Lor), losartan potassium (Los), and ramipril (Ram) in both pure form and pharmaceutical ... |
|
|
Thermally triggered mucoadhesive in situ gel of loratadine: β-cyclodextrin complex for nasal delivery.
AAPS PharmSciTech 14(1) , 412-24, (2013) The aim of the present study was to increase the solubility of an anti-allergic drug loratadine by making its inclusion complex with β-cyclodextrin and to develop it's thermally triggered mucoadhesive in situ nasal gel so as to overcome first-pass effect and ... |
|
|
Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions.
PLoS Comput. Biol. 8(8) , e1002614, (2012) Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we combined a literature discovery approach with analysis of a large electronic medical record database method to predict and evaluate novel DDIs. We predicted an initial ... |