Sch 37370

Names

[ Name ]:
Sch 37370

[Synonym ]:
N-Acetyldesloratadine
PegCNTF
RESPATADINE
Loratadine Impurity 11

Biological Activity

[Description]:

N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4.

Chemical & Physical Properties

[ Density]:
1.257g/cm3

[ Boiling Point ]:
546.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₁ClN₂O

[ Molecular Weight ]:
352.85700

[ Flash Point ]:
284.5ºC

[ Exact Mass ]:
352.13400

[ PSA ]:
33.20000

[ LogP ]:
4.21570

[ Vapour Pressure ]:
5.15E-12mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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