SCH 221510

Names

[ Name ]:
SCH 221510

[Synonym ]:
MM 77 dihydrochloride
3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
SCH 221510

Biological Activity

[Description]:

SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[Target]

EC50: 12 nM (NOP)[1]

[References]

[1]. Varty GB, et al. The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J Pharmacol Exp Ther. 2008 Aug;326(2):672-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₁NO

[ Molecular Weight ]:
397.55

[ Exact Mass ]:
397.24100

[ PSA ]:
23.47000

[ LogP ]:
5.84530

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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