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146-77-0

146-77-0 structure
146-77-0 structure
  • Name: 2-Chloroadenosine
  • Chemical Name: 2-Chloroadenosine
  • CAS Number: 146-77-0
  • Molecular Formula: C10H12ClN5O4
  • Molecular Weight: 301.686
  • Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
  • Create Date: 2018-05-13 08:00:00
  • Modify Date: 2025-08-20 17:44:03
  • 2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].
Name 2-Chloroadenosine
Synonyms 6-Amino-2-chloro-9-(β-D-ribofuranosyl)purine Hydrate
2-CADO,6-Amino-2-chloropurine riboside
2-Chloroadenosine
6-Amino-2-chloropurine Riboside Hydrate
2-CADO Hydrate
EINECS 205-678-3
(2R,3R,4S,5R)-2-(6-Amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol
MFCD00005734
Adenosine, 2-chloro-
2-Chlor-9-(β-D-ribofuranosyl)-9H-purin-6-amin
6-Amino-2-Chloropurine Riboside
2-chloro adenosine
Description 2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].
Related Catalog
References

[1]. Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41.

[2]. Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92.
Density 2.2±0.1 g/cm3
Boiling Point 643.3±65.0 °C at 760 mmHg
Melting Point 162 °C
Molecular Formula C10H12ClN5O4
Molecular Weight 301.686
Flash Point 342.8±34.3 °C
Exact Mass 301.057770
PSA 139.54000
LogP -0.46
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.912
Water Solubility H2O: 10 mg/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7357550
CHEMICAL NAME :
Adenosine, 2-chloro-
CAS REGISTRY NUMBER :
146-77-0
BEILSTEIN REFERENCE NO. :
0043957
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H12-Cl-N5-O4
MOLECULAR WEIGHT :
301.72
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ GG IZ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 118,95,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 118,95,1959 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
603 ug/kg
SEX/DURATION :
female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),35A,1982
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AU7357550
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