5-Amino-4-imidazolecarboxamide

Names

[ CAS No. ]:
360-97-4

[ Name ]:
5-Amino-4-imidazolecarboxamide

[Synonym ]:
4-AMino-5-carbaMoyliMidazole
4(5)-aminoimidazole-5(4)-carboxamide
5-aminoimidazole-4-carboxamide
diazol-c
5-amino-4-imidazole carboxamide
4-Amino-5-imidazolecarboxamide
T5M CNJ DVZ EZ
MFCD02181040
EINECS 206-641-4
4-aminoimidazole-5-carboxamide
ba2756
5-Amino-4-imidazolecarboxamide
aminoimidazolecarboxamide
4-amino-5-imidazolecarboxamid
4-Amino-5-imodazole
aic
4-Aminoimidzole-5-carboxamide
5-Amino-Imidazole-4-carboxamide
5-amino-1H-imidazole-4-carboxamide
4-Amino-1H-imidazole-5-carboxamide
T5M CNJ DZ EVZ
5-AMINO-1H-IMIDAZOLE 4-CARBOXAMIDE
Dacarbazine Impurity 2

Biological Activity

[Description]:

5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. YANG LIU. VARIABLE-TEMPERATURE 1 H-NMR AND AB INITIO STUDY OF 5-AMINO-IMIDAZOLE-4-CARBOXAMIDE (AICA): COMPETING PATHS FOR AMIDE-H SCRAMBLING. DECEMBER 2008.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
535.4±60.0 °C at 760 mmHg

[ Melting Point ]:
164-170 °C(lit.)

[ Molecular Formula ]:
C₄H₆N₄O

[ Molecular Weight ]:
126.117

[ Flash Point ]:
277.6±32.9 °C

[ Exact Mass ]:
126.054161

[ PSA ]:
97.79000

[ LogP ]:
-1.01

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.799

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3910000

CHEMICAL NAME :: Imidazole-4-carboxamide, 5-amino-

CAS REGISTRY NUMBER :: 360-97-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H6-N4-O

MOLECULAR WEIGHT :: 126.14

WISWESSER LINE NOTATION :: T5M CNJ DVZ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22750 mg/kg/13W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2275 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6390 mg/kg/21W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 3 mmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NI3910000

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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