5-Amino-4-imidazolecarboxamide
5-Amino-4-imidazolecarboxamide structure
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Common Name | 5-Amino-4-imidazolecarboxamide | ||
|---|---|---|---|---|
| CAS Number | 360-97-4 | Molecular Weight | 126.117 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 535.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C4H6N4O | Melting Point | 164-170 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 277.6±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Differential effects of AMPK agonists on cell growth and metabolism.
Oncogene 34 , 3627-39, (2015) As a sensor of cellular energy status, the AMP-activated protein kinase (AMPK) is believed to act in opposition to the metabolic phenotypes favored by proliferating tumor cells. Consequently, compounds known to activate AMPK have been proposed as cancer thera... |
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Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.
J. Nutr. 144(12) , 1887-95, (2014) Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are the main products of microbial fermentation in the gut and might mediate some of the effects of gut microbiota and nutrition on development, metabolism, and pathogenesis of obes... |
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Molecular characterization, fitness and mycotoxin production of benzimidazole-resistant isolates of Penicillium expansum.
Int. J. Food Microbiol. 162(3) , 237-44, (2013) Penicillium expansum field-strains resistant to benzimidazole fungicides were isolated in high frequency from decayed apple fruit collected from packinghouses and processing industries located in the region of Imathia, N. Greece. In vitro fungitoxicity tests ... |
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Resistance to fludioxonil in Botrytis cinerea isolates from blackberry and strawberry.
Phytopathology 104(7) , 724-32, (2014) Site-specific fungicides, including the phenylpyrrole fludioxonil, are frequently used for gray mold control but are at risk for the development of resistance. In this study, field isolates that were low-resistant (LR) and moderately resistant (MR) to fludiox... |
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Characterization of iprodione resistance in Botrytis cinerea from strawberry and blackberry.
Phytopathology 104(4) , 396-402, (2014) Gray mold, caused by the fungal pathogen Botrytis cinerea, is one of the most destructive diseases of strawberry. Control of the disease in commercial fields is largely dependent on the application of fungicides, including the dicarboximide iprodione. Single-... |
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Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.
J. Neurosci. 34(31) , 10192-205, (2014) Excitotoxicity is a condition occurring during cerebral ischemia, seizures, and chronic neurodegeneration. It is characterized by overactivation of glutamate receptors, leading to excessive Ca(2+)/Na(+) influx into neurons, energetic stress, and subsequent ne... |
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AMPK and FoxO1 regulate catalase expression in hypoxic pulmonary arterial smooth muscle.
Pediatr. Pulmonol. 49(9) , 885-97, (2014) Hypoxia and reactive oxygen species (ROS) including H(2)O(2) play major roles in triggering and progression of pulmonary vascular remodeling in persistent pulmonary hypertension. Catalase (CAT), the major endogenous enzyme scavenging H(2)O(2), is regulated in... |
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Exometabolom analysis of breast cancer cell lines: Metabolic signature.
Sci. Rep. 5 , 13374, (2015) Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of different subtypes of breast cancer cell lines and the breast epith... |
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AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer.
Oncotarget 6 , 14754-65, (2015) AMP-activated Protein Kinase (AMPK) activity retards growth of many types of cancers. Investigating effects of AMPK activation on breast cancer cell signaling and survival, we found that breast cancer cell lines with amplification and over-expression of HER2 ... |
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Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.
Monatsh. Chem 146 , 1315-1327, (2015) We reported the synthesis and characterization of a series of azolo- and azino[1,3]thiazinones containing the 2,4-dihydroxyphenyl substituent. The compounds were prepared by a new one-step reaction of aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethio... |