Aica ribonucleotide

Names

[ Name ]:
Aica ribonucleotide

[Synonym ]:
EINECS 221-212-1
MFCD00057264
5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-β-D-RIBOFURANOSYL 5'-MONOPHOSPHATE

Biological Activity

[Description]:

AICA-riboside, 5′-phosphate (AICAR-5'-MP) is a 5'-phosphorylated analogue of AICAR. AICAR is an adenosine analog and a AMPK activator. [1].

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
2.3g/cm3

[ Boiling Point ]:
845.3ºC at 760 mmHg

[ Melting Point ]:
198-202ºC dec.

[ Molecular Formula ]:
C₉H₁₅N₄O₈P

[ Molecular Weight ]:
338.21

[ Flash Point ]:
465ºC

[ Exact Mass ]:
338.06300

[ PSA ]:
213.19000

[ Index of Refraction ]:
1.831

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.

Br. J. Cancer 111(8) , 1562-71, (2014)

The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk.We investi...

Site-directed mutagenesis of catalytic residues in N(5)-carboxyaminoimidazole ribonucleotide synthetase.

Biochemistry 52(37) , 6559-67, (2013)

N(5)-CAIR synthetase, an essential enzyme in microorganisms, converts 5-aminoimidazole ribonucleotide (AIR) and bicarbonate to N(5)-CAIR with the aid of ATP. Previous X-ray crystallographic analyses o...

Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages.

PLoS ONE 7(12) , e53101, (2012)

Genistein, the major isoflavone in soybean, was recently reported to exert beneficial effects in metabolic disorders and inflammatory diseases. In the present study, we investigated the effects and me...