8-hydroxy-2'-deoxyguanosine

Names

[ Name ]:
8-hydroxy-2'-deoxyguanosine

[Synonym ]:
2'-deoxy-7,8-dihydro-8-oxo-guanosine
MFCD00210311
2'-Deoxy-8-oxo-7,8-dihydroguanosine
7,8-Dihydro-8-oxo-2'-deoxyguanosine
2'-Deoxy-8-oxoguanosine
8-Oxo-7,8-dihydrodeoxyguanosine
2'-Deoxy-8-oxo-D-guanosine
8-Oxodeoxyguanosine
guanosine, 2'-deoxy-8-oxo-
2'-Deoxy-8-hydroxyguanosine
8-oxo-7,8-dihydro-2'-deoxiguanosine
Guanosine, 2'-deoxy-8-hydroxy-
8-oxo-7-hydrodeoxyguanosine
8-hydroxydeoxyguanosine
8-HYDROXY-2'-DEOXYGUANOSINE
8-Hydroxy-2’-deoxyguanosine
8-oxo-7,8-dihydro-2'-deoxyguanosine
2'-Deoxy-7,8-dihydro-8-oxoguanosine

Biological Activity

[Description]:

8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.

[Related Catalog]:

Research Areas >> Cancer

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons[1].

[References]

[1]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.3±0.1 g/cm3

[ Melting Point ]:
217-220ºC

[ Molecular Formula ]:
C₁₀H₁₃N₅O₅

[ Molecular Weight ]:
283.241

[ Exact Mass ]:
283.091675

[ PSA ]:
159.51000

[ LogP ]:
-1.32

[ Index of Refraction ]:
1.955

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MF8782675

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury.

Free Radic. Biol. Med. 74 , 263-73, (2014)

NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury, but limited information is available about NADPH oxidase in renal ischemia/r...

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells.

Oncotarget 6 , 36245-59, (2015)

Tyrosine kinase inhibitors (TKIs) including axitinib have been introduced in the treatment of renal cell carcinoma (RCC) because of their anti-angiogenic properties. However, no evidence are presently...

Effect of long-term human exposure to environmental heavy metals on the expression of detoxification and DNA repair genes.

Environ. Pollut. 181 , 226-32, (2013)

The present study was designed to evaluate the influence of long-term environmental human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the expression of detoxifying, x...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.