8-Bromo-2'-deoxyguanosine

Names

[ Name ]:
8-Bromo-2'-deoxyguanosine

[Synonym ]:
2'-Deoxy-8-bromoguanosine
C8-bromo-2'-deoxyguanosine
Guanosine, 8-bromo-2'-deoxy-
8-Br-dG
8-bromo-2'-deoxyuanosine
8-Bromo-2'-deoxyguanosine
8-Bromo-2'-deoxy-D-guanosine
2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
8-bromo2'-deoxyguansine

Biological Activity

[Description]:

8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.5±0.1 g/cm3

[ Boiling Point ]:
727ºC at 760 mmHg

[ Melting Point ]:
>250ºC dec.

[ Molecular Formula ]:
C₁₀H₁₂BrN₅O₄

[ Molecular Weight ]:
346.14

[ Flash Point ]:
393.5ºC

[ Exact Mass ]:
345.007263

[ PSA ]:
139.28000

[ LogP ]:
-0.02

[ Appearance of Characters ]:
Powder | White to Off-white

[ Vapour Pressure ]:
3.46E-22mmHg at 25°C

[ Index of Refraction ]:
1.941

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
Soluble in dimethyl sulfoxide, warm water and dimethyl formamide.

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T+

Synthetic Route

Click to get detail synthetic route

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.