8-hydroxy-2'-deoxyguanosine
8-hydroxy-2'-deoxyguanosine structure
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Common Name | 8-hydroxy-2'-deoxyguanosine | ||
|---|---|---|---|---|
| CAS Number | 88847-89-6 | Molecular Weight | 283.241 | |
| Density | 2.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H13N5O5 | Melting Point | 217-220ºC | |
| MSDS | USA | Flash Point | N/A | |
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Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury.
Free Radic. Biol. Med. 74 , 263-73, (2014) NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury, but limited information is available about NADPH oxidase in renal ischemia/reperfusion injury. Our aim was to investigate the activatio... |
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Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells.
Oncotarget 6 , 36245-59, (2015) Tyrosine kinase inhibitors (TKIs) including axitinib have been introduced in the treatment of renal cell carcinoma (RCC) because of their anti-angiogenic properties. However, no evidence are presently available on a direct cytotoxic anti-tumor activity of axi... |
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Effect of long-term human exposure to environmental heavy metals on the expression of detoxification and DNA repair genes.
Environ. Pollut. 181 , 226-32, (2013) The present study was designed to evaluate the influence of long-term environmental human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the expression of detoxifying, xenobiotic metabolizing, and DNA repair genes in Mahd Ad-Dah... |
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Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis.
J. Pineal Res. 58(1) , 34-49, (2014) Mucositis is a common and distressing side effect of chemotherapy or radiotherapy that has potentially severe consequences, and no treatment is available. The purpose of this study was to analyze the molecular pathways involved in the development of oral muco... |
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Viscous methyl cellulose solution thickens gastric mucosa and increases the number of gland mucous cells in mice.
Br. J. Nutr. 110(7) , 1195-200, (2013) We have observed a stiffening of the gastric wall in mice following oral administration of viscous methyl cellulose (MC) solution as a vehicle for food chemicals, an effect which has not previously been reported. To further investigate this effect, young male... |
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L-cysteine: a biocompatible, breathable and beneficial coating for graphene oxide.
Biomaterials 52 , 301-11, (2015) Graphene oxide (GO) has been employed in various fields, and its ecological and health risks have attracted much attention. A small and inexpensive biomolecule, L-cysteine, was covalently immobilized onto GO to form L-cysteine-GO (CysGO) as a thio-functionali... |
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Expression of airway remodeling proteins in mast cell activated by TGF-β released in OVA-induced allergic responses and their inhibition by low-dose irradiation or 8-oxo-dG.
Radiat. Res. 181(4) , 425-38, (2014) Allergic asthma is characterized by chronic airway remodeling, which is associated with the expression of extracellular matrix proteins (ECM) by TGF-β. However, to date there are no reports demonstrating that structural proteins are directly expressed in mast... |
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Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients.
PLoS ONE 10 , e0143865, (2015) Recent evidence suggests that GSK3 activity is chondroprotective in osteoarthritis (OA), but at the same time, its inactivation has been proposed as an anti-inflammatory therapeutic option. Here we evaluated the extent of GSK3β inactivation in vivo in OA knee... |
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Multi-element distribution profile in Sprague-Dawley rats: Effects of intratracheal instillation of Cr(VI) and Zn intervention
Toxicol. Lett. 226(2) , 198-205, (2014) • We studied how Cr(VI) exposure individually affected the element distribution in target organs and tissues. • The more susceptible tissues like RBC were found, which would contribute to the future studying of early sensitive health impact of Cr(VI). • This ... |
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Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.
Toxicol. Appl. Pharmacol. 274(2) , 313-8, (2014) Inhibition of DNA repair is a recognized mechanism for arsenic enhancement of ultraviolet radiation-induced DNA damage and carcinogenesis. Poly(ADP-ribose) polymerase-1 (PARP-1), a zinc finger DNA repair protein, has been identified as a sensitive molecular t... |