Toxicology Letters 2014-04-21

Multi-element distribution profile in Sprague-Dawley rats: Effects of intratracheal instillation of Cr(VI) and Zn intervention

Yanshuang Song, Tianjing Wang, Ji Pu, Jian Guo, Zhangjian Chen, Yun Wang, Guang Jia

Index: Toxicol. Lett. 226(2) , 198-205, (2014)

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Abstract

• We studied how Cr(VI) exposure individually affected the element distribution in target organs and tissues. • The more susceptible tissues like RBC were found, which would contribute to the future studying of early sensitive health impact of Cr(VI). • This is the first in vivo study to investigate the interfering role of Zn intervention on Cr(VI) induced element imbalance and its relationship with oxidative stress.