4-Methoxycinnamic acid
Names
[ CAS No. ]:
830-09-1
[ Name ]:
4-Methoxycinnamic acid
[Synonym ]:
3-(4-Methoxy-phenyl)-acrylic acid
trans-4-Methoxycinnamic acid
4-MeOC6H4CH=CHCOOH
4-methoxycinnamate
RARECHEM BK HC T257
2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)-
2-Propenoic acid, 3- (4-methoxyphenyl)-
(E)-3-(4-methoxyphenyl)acrylic acid
4-Methoxy-(2E)-cinnamic acid
4-Methoxyciamic acid
p-coumaric acid methyl ether
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
UNII-6G4ML8401A
(E)-p-methoxycinnamic acid
4-Methoxycinnamic acid
(2E)-3-(4-Methoxyphenyl)acrylic acid
4-methoxy-(E)-cinnamic acid
EINECS 213-405-4
(E)-3-(4-Methoxyphenyl)acrylate
para-methoxycinnamic acid
PMCA
MFCD00004398
(2E)-3-(4-Methoxyphenyl)-2-propenoic acid
para-methoxycinnamate
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[In Vitro]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
342.6±17.0 °C at 760 mmHg
[ Melting Point ]:
173.5 °C(lit.)
[ Molecular Formula ]:
C10H10O3
[ Molecular Weight ]:
178.185
[ Flash Point ]:
138.6±14.4 °C
[ Exact Mass ]:
178.062988
[ PSA ]:
46.53000
[ LogP ]:
2.36
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.591
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UD3391300
- CHEMICAL NAME :
- 2-Propenoic acid, 3-(4-methoxyphenyl)-
- CAS REGISTRY NUMBER :
- 830-09-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C10-H10-O3
- MOLECULAR WEIGHT :
- 178.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1300 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)
- REFERENCE :
- IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UD3391300
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Nucl. Med. 139 , 2309-14, (2009)
Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...
Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg. Med. Chem. Lett. 15 , 1949-53, (2005)
1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC(50) value of 2.3 micr...
Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)
Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...