DL-Norvaline

Names

[ CAS No. ]:
760-78-1

[ Name ]:
DL-Norvaline

[Synonym ]:
DL-NORVALINE
α-DL-Aminopentanoic acid
DL-2-Aminovaleric Acid
2-Aminovaleric acid
MFCD00064420
DL-norVal-OH
DL-2-Aminopentanoic acid
(±)-2-Aminopentanoic acid
H-DL-Nva-OH
rac-norvaline
a-Aminovaleric Acid
2-Aminopentanoic acid
EINECS 212-082-7
APE
DL-α-Aminovaleric acid
Norvaline
Norvaline, DL-
NVA
UNII:V639KTF2SZ
Norvaline (VAN)
(±)-Norvaline
aminovaleric acid

Biological Activity

[Description]:

DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Arginase

Research Areas >> Metabolic Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2].

[Cell Assay]

A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1].

[References]

[1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50.

[2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
222.9±23.0 °C at 760 mmHg

[ Melting Point ]:
≥300 °C (dec.)

[ Molecular Formula ]:
C₅H₁₁NO₂

[ Molecular Weight ]:
117.146

[ Flash Point ]:
88.6±22.6 °C

[ Exact Mass ]:
117.078979

[ PSA ]:
63.32000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
1 g/10 mL (18 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29224995

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Related Compounds

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