DL-Norvaline

Modify Date: 2025-08-22 11:17:43

DL-Norvaline Structure
DL-Norvaline structure
 Common Name DL-Norvaline
CAS Number 760-78-1 Molecular Weight 117.146
Density 1.1±0.1 g/cm3 Boiling Point 222.9±23.0 °C at 760 mmHg
Molecular Formula C5H11NO2 Melting Point ≥300 °C (dec.)
MSDS USA Flash Point 88.6±22.6 °C

 Use of DL-Norvaline


DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

 Names

Name 2-aminopentanoic acid
Synonym More Synonyms

 DL-Norvaline Biological Activity

Description DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2].
Cell Assay A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1].
References

[1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50.

[2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 222.9±23.0 °C at 760 mmHg
Melting Point ≥300 °C (dec.)
Molecular Formula C5H11NO2
Molecular Weight 117.146
Flash Point 88.6±22.6 °C
Exact Mass 117.078979
PSA 63.32000
LogP 0.38
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.464
Storage condition Store at RT.
Water Solubility 1 g/10 mL (18 ºC)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29224995

 Synthetic Route

 Customs

HS Code 29224995

 Articles40

More Articles
Mouse hepatocytes and LSEC proteome reveal novel mechanisms of ischemia/reperfusion damage and protection by A2aR stimulation.

J. Hepatol. 62(3) , 573-80, (2015)

Ischemia-reperfusion (IR) of liver results in hepatocytes (HP) and sinusoidal endothelial cells (LSEC) irreversible damage. Ischemic preconditioning protects IR damage upon adenosine A2a receptor (A2a...

Analysis of beers from an 1840s' shipwreck.

J. Agric. Food Chem. 63(9) , 2525-36, (2015)

Two bottles of beer from an about 170-year-old shipwreck (M1 Fö 403.3) near the Åland Islands in the Baltic Sea were analyzed. Hop components and their degradation compounds showed that the bottles co...

Teicoplanin bonded sub-2 μm superficially porous particles for enantioseparation of native amino acids.

J. Pharm. Biomed. Anal. 114 , 247-53, (2015)

Superficially porous particles (SPPs) demonstrate superior efficiency than totally porous particles in chiral separations. In order to obtain high efficiency and fast separation, sub-2 μm SPPs with hi...

 Synonyms

DL-NORVALINE
α-DL-Aminopentanoic acid
DL-2-Aminovaleric Acid
2-Aminovaleric acid
MFCD00064420
DL-norVal-OH
DL-2-Aminopentanoic acid
(±)-2-Aminopentanoic acid
H-DL-Nva-OH
rac-norvaline
a-Aminovaleric Acid
2-Aminopentanoic acid
EINECS 212-082-7
APE
DL-α-Aminovaleric acid
Norvaline
Norvaline, DL-
NVA
UNII:V639KTF2SZ
Norvaline (VAN)
(±)-Norvaline
aminovaleric acid
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Chemsrc provides DL-Norvaline(CAS#:760-78-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DL-Norvaline are included as well.>> amp version: DL-Norvaline

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