Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: DL-Norvaline
Price: ￥1348.0/500g ￥298.0/100g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DL-Norvaline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: DL-Norvaline
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-aminopentanoic acid(760-78-1)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

760-78-1

760-78-1 structure

760-78-1 structure

Name: DL-Norvaline
Chemical Name: 2-aminopentanoic acid
CAS Number: 760-78-1
Molecular Formula: C₅H₁₁NO₂
Molecular Weight: 117.146
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2018-08-03 17:23:20
Modify Date: 2024-01-02 01:04:31
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

Name	2-aminopentanoic acid
Synonyms	DL-NORVALINE α-DL-Aminopentanoic acid DL-2-Aminovaleric Acid 2-Aminovaleric acid MFCD00064420 DL-norVal-OH DL-2-Aminopentanoic acid (±)-2-Aminopentanoic acid H-DL-Nva-OH rac-norvaline a-Aminovaleric Acid 2-Aminopentanoic acid EINECS 212-082-7 APE DL-α-Aminovaleric acid Norvaline Norvaline, DL- NVA UNII:V639KTF2SZ Norvaline (VAN) (±)-Norvaline aminovaleric acid

Description	DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Arginase Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2].
Cell Assay	A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1].
References	[1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50. [2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200.

Density	1.1±0.1 g/cm3
Boiling Point	222.9±23.0 °C at 760 mmHg
Melting Point	≥300 °C (dec.)
Molecular Formula	C₅H₁₁NO₂
Molecular Weight	117.146
Flash Point	88.6±22.6 °C
Exact Mass	117.078979
PSA	63.32000
LogP	0.38
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.464
Storage condition	Store at RT.
Water Solubility	1 g/10 mL (18 ºC)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29224995

Precursor 9
1821-02-9 56548-09-5 82518-89-6 6967-47-1
64527-14-6 74-90-8 40898-95-1 623-11-0
7647-01-0
DownStream 10
21691-43-0 109-52-4 7682-15-7 6600-40-4
57357-56-9 2013-12-9 71-36-3 1821-02-9
123-72-8 107-92-6

HS Code	29224995