N-nicotinoyl-Glycine

Names

[ CAS No. ]:
583-08-4

[ Name ]:
N-nicotinoyl-Glycine

[Synonym ]:
Nicotinursaeure
N-Nicotinylglycine
Glycine, N-(3-pyridinylcarbonyl)-
N-(Pyridin-3-ylcarbonyl)glycine
Nicotinuric acid
N-(3-Pyridinylcarbonyl)glycine
Nicotinylglycine
Nicotinurate
[(3-pyridinylcarbonyl)amino]acetic acid
nicotinicamido acetic acid
Glycine,N-nicotinoyl
Nicotinoyl-Glycine
EINECS 209-497-0
MFCD00023578
N-(3-pyridinylcarbonyl)-glycine
N-nicotinoyl-Glycine
2-(pyridine-3-carbonylamino)acetic acid

Biological Activity

[Description]:

Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid.

[Related Catalog]:

Research Areas >> Others

Natural Products >> Acids and Aldehydes

[Target]

Human Endogenous Metabolite

[References]

[1]. Inamadugu JK, et al. Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomed Chromatogr. 2010 Oct;24(10):1059-74.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
512.5±30.0 °C at 760 mmHg

[ Melting Point ]:
256-2580C (dec.)

[ Molecular Formula ]:
C₈H₈N₂O₃

[ Molecular Weight ]:
180.161

[ Flash Point ]:
263.7±24.6 °C

[ Exact Mass ]:
180.053497

[ PSA ]:
79.29000

[ LogP ]:
-0.55

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
Store at 0-5°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.

Kidney Int. 79(11) , 1244-53, (2011)

Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...

Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.

Biosci. Biotechnol. Biochem. 68(1) , 44-50, (2004)

We investigated a useful chemical index for an excessive nicotinamide intake and how this excessive nicotinamide intake affects the tryptophan-nicotinamide metabolism in rats. Weaning rats were fed on...

Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.

Int. J. Clin. Pharmacol. Ther. 45(8) , 448-54, (2007)

To characterize plasma and urine pharmacokinetics of niacin and its metabolites after oral administration of 2,000 mg of extended-release (ER) niacin in healthy male volunteers.Niacin ER was administe...