nicotinoyl azide

Names

[ Name ]:
nicotinoyl azide

[Synonym ]:
3-pyridylcarbonyl azide
3-pyridinecarboxylic acid azide
NICOTINOYL AZIDE
nicotynic acid azide
azido(pyridin-3-yl)methanone
pyridine-3-carboxylic acid azide
3-Pyridinecarbonyl azide (9CI)
Nicotinic acid azide
3-Pyridinecarbonylazide

Biological Activity

[Description]:

Nicotinoyl azide is capable of forming high energy intermediates known to form C-8 adducts with adenosine and guanosine[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Chao Feng, et al. Light-activated chemical probing of nucleobase solvent accessibility inside cells. Nat Chem Biol. 2018 Mar;14(3):276-283.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₄N₄O

[ Molecular Weight ]:
148.12200

[ Exact Mass ]:
148.03900

[ PSA ]:
79.71000

[ LogP ]:
0.98486

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT3325000

CHEMICAL NAME :: Nicotinoyl azide

CAS REGISTRY NUMBER :: 4013-72-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H4-N4-O

MOLECULAR WEIGHT :: 148.14

WISWESSER LINE NOTATION :: T6NJ CVNNN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 108,473,1956

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 166 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,692,1955

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%