N-nicotinoyl-Glycine
N-nicotinoyl-Glycine structure
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Common Name | N-nicotinoyl-Glycine | ||
|---|---|---|---|---|
| CAS Number | 583-08-4 | Molecular Weight | 180.161 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 512.5±30.0 °C at 760 mmHg | |
| Molecular Formula | C8H8N2O3 | Melting Point | 256-2580C (dec.) | |
| MSDS | Chinese USA | Flash Point | 263.7±24.6 °C | |
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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.
Kidney Int. 79(11) , 1244-53, (2011) Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (... |
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Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
Biosci. Biotechnol. Biochem. 68(1) , 44-50, (2004) We investigated a useful chemical index for an excessive nicotinamide intake and how this excessive nicotinamide intake affects the tryptophan-nicotinamide metabolism in rats. Weaning rats were fed on a tryptophan-limited and nicotinic acid-free diet containi... |
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Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.
Int. J. Clin. Pharmacol. Ther. 45(8) , 448-54, (2007) To characterize plasma and urine pharmacokinetics of niacin and its metabolites after oral administration of 2,000 mg of extended-release (ER) niacin in healthy male volunteers.Niacin ER was administered to 12 healthy male subjects following a low-fat snack. ... |
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Niacin catabolism in rodents.
J. Nutr. Sci. Vitaminol. 36(2) , 87-98, (1990) Urinary excretion of nicotinamide and its metabolites in mouse, guinea pig, and hamster with a pharmacological amount of nicotinamide or N1-methylnicotinamide (MNA) was investigated to compare them with those of rat. In mouse, nicotinamide N-oxide was the mos... |
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Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites.
J. Clin. Pharmacol. 47(6) , 681-8, (2007) The metabolic profile of niacin is influenced by the rate of niacin administration. This study characterizes the effect of administration rate on the pharmacokinetics of niacin and its metabolites. Twelve healthy males were enrolled in an open-label, dose-rat... |
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Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry.
J. Chromatogr. A. 1422 , 89-98, (2015) This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol en... |
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High-performance liquid-chromatographic determination of free nicotinic acid and its metabolite, nicotinuric acid, in plasma and urine.
Clin. Chem. 24(10) , 1740-3, (1978) We report a liquid-chromatographic procedure for determining free nicotinic acid and a metabolite, nicotinuric acid, in plasma and urine. Five-tenths milliliter of urine or deproteinized plasma is evaporated and the residue analyzed isocratically by reversed-... |
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Acute dose-dependent disposition studies of nicotinic acid in rats.
Drug Metab. Dispos. 24(7) , 773-9, (1996) The pharmacokinetics of nicotinic acid (NiAc) and nicotinuric acid (NiUAc), the major metabolite of NiAc, and the dose dependency of these pharmacokinetics were determined in rats. Intravenous injections of 2, 5, 15, and 45 mg/kg of NiAc and 5 and 15 mg/kg of... |
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Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man.
J. Clin. Pharmacol. 28(12) , 1136-40, (1988) We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recover... |
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A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week.
J. Nutr. 143(6) , 766-73, (2013) Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may ... |