L-Aspartic acid

Names

[ CAS No. ]:
56-84-8

[ Name ]:
L-Aspartic acid

[Synonym ]:
asparagic acid
1-amino-1,2-carboxyethane
δ-aspartic acid
d-Asp
QVYZ1VQ &&D or R Form
(-)-Aspartic acid
(2R)-2-Aminosuccinic acid
MFCD00002616
(2R)-2-aminobutanedioic acid
hydrogen D-aspartate
L-Asparticacid
(R)-(−)-Aminosuccinic acid
D-(-)-Aspartic acid
Acide (2R)-2-aminosuccinique
L-Aspartic acid
aspartic acid D-form
Aspartic acid, D-
D-Aspartic acid
H-D-Asp-OH
EINECS 200-291-6
H-Asp-OH

Biological Activity

[Description]:

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Cardiovascular Disease

[Target]

Human Endogenous Metabolite

[In Vivo]

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].

[References]

[1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.

[2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
264.1±30.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₇NO₄

[ Molecular Weight ]:
133.103

[ Flash Point ]:
113.5±24.6 °C

[ Exact Mass ]:
133.037506

[ PSA ]:
100.62000

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.531

[ Water Solubility ]:
5 g/L (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9098500

CHEMICAL NAME :: Aspartic acid, L-

CAS REGISTRY NUMBER :: 56-84-8

BEILSTEIN REFERENCE NO. :: 1723530

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H7-N-O4

MOLECULAR WEIGHT :: 133.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25079 mg/kg/7D-C

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;Xn: Harmful;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26-S24/25-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
CI9098500

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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