56-84-8

56-84-8 structure

Name: L-Aspartic acid
Chemical Name: L-aspartic acid
CAS Number: 56-84-8
Molecular Formula: C₄H₇NO₄
Molecular Weight: 133.103
Catalog: Biochemical Amino acids and their derivatives --amino acid
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-02 11:14:54
L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

Name	L-aspartic acid
Synonyms	asparagic acid 1-amino-1,2-carboxyethane δ-aspartic acid d-Asp QVYZ1VQ &&D or R Form (-)-Aspartic acid (2R)-2-Aminosuccinic acid MFCD00002616 (2R)-2-aminobutanedioic acid hydrogen D-aspartate L-Asparticacid (R)-(−)-Aminosuccinic acid D-(-)-Aspartic acid Acide (2R)-2-aminosuccinique L-Aspartic acid aspartic acid D-form Aspartic acid, D- D-Aspartic acid H-D-Asp-OH EINECS 200-291-6 H-Asp-OH

Description	L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.
Related Catalog	Natural Products >> Others Research Areas >> Cardiovascular Disease
Target	Human Endogenous Metabolite
In Vivo	L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].
References	[1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;Xn: Harmful;
Risk Phrases	R36
Safety Phrases	S26-S24/25-S22
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CI9098500
HS Code	29224995

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%