D-methionine
Names
[ CAS No. ]:
348-67-4
[ Name ]:
D-methionine
[Synonym ]:
R-Methionine
(R)-2-amino-4-(methylthio)butanoic acid
Methionine, D-
D-Methionin
d-Met
(2R)-2-amino-4-(methylsulfanyl)butanoic acid
(R)-methionine
D-Methionine
(R)-2-Amino-4-(methylmercapto)butyric acid (D-2-Amino-4-(methylthio)butanoic acid
EINECS 206-483-6
(2R)-2-amino-4-methylsulfanylbutanoic acid
H-D-Met-OH
MFCD00002622
H-D-Met-OEt.HCl
MRX-1024
Biological Activity
[Description]:
[Related Catalog]:
[Target]
GABAA receptor[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
306.9±37.0 °C at 760 mmHg
[ Melting Point ]:
273-275ºC
[ Molecular Formula ]:
C5H11NO2S
[ Molecular Weight ]:
149.211
[ Flash Point ]:
139.4±26.5 °C
[ Exact Mass ]:
149.051056
[ PSA ]:
88.62000
[ LogP ]:
0.37
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.531
[ Storage condition ]:
2~8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PD0455000
- CHEMICAL NAME :
- Methionine, D-
- CAS REGISTRY NUMBER :
- 348-67-4
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C5-H11-N-O2-S
- MOLECULAR WEIGHT :
- 149.23
- WISWESSER LINE NOTATION :
- QVYZ2S1 -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5223 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R33
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
PD0455000
[ HS Code ]:
2930400000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
PLoS ONE 4(5) , e5492, (2009)
The transcription factor Nrf2 is the master regulator of a cellular defense mechanism against environmental insults. The Nrf2-mediated antioxidant response is accomplished by the transcription of a ba...
Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition.J. Neural Transm. Gen. Sect. 121(7) , 683-93, (2014)
Antioxidants are well known for their neuroprotective properties against reactive oxygen species in cortical neurons and auditory cells. We recently identified L-carnitine and D-methionine to be among...
D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies.Hear. Res. 282 , 138-144, (2011)
We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with d-methionine (d-met) administration 1 h after noise exposure. The present study investigat...