L-Selenomethionine

Names

[ Name ]:
L-Selenomethionine

[Synonym ]:
L-Selenomethioninum
(2S)-2-Amino-4-(methylseleno)butanoic acid
(S)-2-Amino-4-(Methylseleno)Butyric Acid
MFCD00037210
(2S)-2-Amino-4-(methylselanyl)butanoic acid
Selenium-L-methionine
Se-methionine
SeMet
L-selenomethionine zwitterion
(S)-2-Amino-4-(methylselanyl)butanoic acid
Seleno-L-methionine
(2S)-2-amino-4-methylselanylbutanoic acid
Butanoic acid, 2-amino-4-(methylseleno)-, (2S)-
L(+)-Selenomethionine
(S)-2-Amino-4-(methylseleno)butanoic acid
L-SelenoMethionine
L-(+)-Selenomethionine
Selenomethionine

Biological Activity

[Description]:

L-SelenoMethionine is a major natural food-form of selenium.Target：The median lethal dose (LD50) of L-SelenoMethionine in rats given an intraperitoneal injection was determined to 4.25 mg Se/kg body and thus is comparable to that of selenite or selenate. In mice, the LD50 of L-SelenoMethionine was 8.8 ± 1.37 mg Se/kg, and the minimal lethal dose, 4.0 mg Se/kg, after intravenous injection.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Schrauzer GN, et al. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-1656.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
320.8±37.0 °C at 760 mmHg

[ Melting Point ]:
265 °C

[ Molecular Formula ]:
C₅H₁₁NO₂Se

[ Molecular Weight ]:
196.106

[ Flash Point ]:
147.8±26.5 °C

[ Exact Mass ]:
196.995499

[ PSA ]:
63.32000

[ LogP ]:
-0.65

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
18 ° (C=0.5, 2mol/L HCl)

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7713840

CHEMICAL NAME :: Butanoic acid, 2-amino-4-(methylseleno)-, (S)-

CAS REGISTRY NUMBER :: 3211-76-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H11-N-O2-Se

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 269 mg/kg/8W-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JTEMEM Journal of Trace Elements in Experimental Medicine. (Wiley-Liss, Inc., 605 Third Ave., New York, NY 10158-0012) V.1- 1988- Volume(issue)/page/year: 4,69,1991

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H331-H373-H410

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P260-P304 + P340 + P312-P403 + P233

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/25;R33;R50/53

[ Safety Phrases ]:
S20/21-S28-S45-S60-S61-S28A

[ RIDADR ]:
UN 3283 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
EK7713840

[ Packaging Group ]:
I; II; III

[ Hazard Class ]:
6.1

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC.

ChemBioChem. 16 , 1490-6, (2015)

The ubiquitous sulfur metabolite ergothioneine is biosynthesized by oxidative attachment of a sulfur atom to the imidazole ring of Nα-trimethylhistidine. Most actinobacteria, including Mycobacterium t...