2,6-Dihydroxybenzoic acid

Names

[ CAS No. ]:
303-07-1

[ Name ]:
2,6-Dihydroxybenzoic acid

[Synonym ]:
EINECS 206-134-8
Gamma-Resorcylic Acid
2-Carboxyresorcinol
γ-Resorcylic acid
Benzoic acid,2,6-dihydroxy
2,6-dihydroxy-benzoic acid
2,5-DIFLUOROBENZYLSULFONAMIDE
2,6-Dihydroxybenzoic acid
g-Resorcylic Acid
2,6-Resorcylic acid
6-Hydroxysalicylic acid
MFCD00002462
Benzoic acid, 2,6-dihydroxy-

Biological Activity

[Description]:

2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Cokgor EU, et al. Biodegradation kinetics of peptone and 2,6-dihydroxybenzoic acid by acclimated dual microbial culture. Bioresour Technol. 2011 Jan;102(2):567-75.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
343.7±32.0 °C at 760 mmHg

[ Melting Point ]:
165 °C (dec.)(lit.)

[ Molecular Formula ]:
C₇H₆O₄

[ Molecular Weight ]:
154.120

[ Flash Point ]:
175.8±21.6 °C

[ Exact Mass ]:
154.026611

[ PSA ]:
77.76000

[ LogP ]:
2.24

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.671

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8578000

CHEMICAL NAME :: Benzoic acid, 2,6-dihydroxy-

CAS REGISTRY NUMBER :: 303-07-1

BEILSTEIN REFERENCE NO. :: 2209755

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H6-O4

MOLECULAR WEIGHT :: 154.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 196,478,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1392,1969

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG8578000

[ HS Code ]:
29182990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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