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MC-Val-Cit-PAB-OH

Names

[ CAS No. ]:
159857-80-4

[ Name ]:
MC-Val-Cit-PAB-OH

[Synonym ]:
MC-Val-Cit-PAB

Biological Activity

[Description]:

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Cancer

[Target]

ADC linker[1]


[References]

[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders


[Related Small Molecules]

Val-cit-PAB-OH | Mc-Val-Cit-PABC-PNP | Fmoc-Val-Cit-PAB-PNP | N-Succinimidyl 6-maleimidohexanoate | 6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- | Fmoc-Val-Cit-PAB-OH | DC1 | DC1-SMe | UAA crosslinker 1

Chemical & Physical Properties

[ Density]:
1.276

[ Molecular Formula ]:
C28H40N6O7

[ Molecular Weight ]:
572.65300

[ Exact Mass ]:
572.29600

[ PSA ]:
210.70000

[ LogP ]:
3.27310

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds